Статья

Smart Nanotubes for Bioseparations and Biocatalysis

David T. MitchellDepartment of Chemistry and Center for Research at the Bio/Nano Interface, University of Florida, Gainesville, Florida 32611-7200 and VTT Biotechnology, PO Box 1500, FIN-02044 VTT Espoo, FinlandSang Bok LeeDepartment of Chemistry and Center for Research at the Bio/Nano Interface, University of Florida, Gainesville, Florida 32611-7200 and VTT Biotechnology, PO Box 1500, FIN-02044 VTT Espoo, FinlandLǎcrǎmioara TrofinDepartment of Chemistry and Center for Research at the Bio/Nano Interface, University of Florida, Gainesville, Florida 32611-7200 and VTT Biotechnology, PO Box 1500, FIN-02044 VTT Espoo, FinlandNaichao LiDepartment of Chemistry and Center for Research at the Bio/Nano Interface, University of Florida, Gainesville, Florida 32611-7200 and VTT Biotechnology, PO Box 1500, FIN-02044 VTT Espoo, FinlandTarja K. NevanenDepartment of Chemistry and Center for Research at the Bio/Nano Interface, University of Florida, Gainesville, Florida 32611-7200 and VTT Biotechnology, PO Box 1500, FIN-02044 VTT Espoo, FinlandHans SöderlundDepartment of Chemistry and Center for Research at the Bio/Nano Interface, University of Florida, Gainesville, Florida 32611-7200 and VTT Biotechnology, PO Box 1500, FIN-02044 VTT Espoo, FinlandCharles R. MartinDepartment of Chemistry and Center for Research at the Bio/Nano Interface, University of Florida, Gainesville, Florida 32611-7200 and VTT Biotechnology, PO Box 1500, FIN-02044 VTT Espoo, Finland

2002en

ABI

Аннотация

Tube-shaped nanostructures (nanotubes) have a number of attributes that make them potentially useful for biomedical applications such as drug delivery/detoxification and enzyme immobilization. Template synthesis provides a route for preparing monodisperse nanotubes of nearly any size and composed of nearly any material. We show here that template-synthesized silica nanotubes can be biochemically functionalized such that they act as biocatalysts and highly selective nano-phase extraction agents for bioseparations. For example, nanotubes containing an enantioselective antibody selectively extract the enantiomer of a drug molecule that binds to the antibody, relative to the enantiomer that has no specific interaction with the antibody. Nanotubes containing the enzyme glucose oxidase function as nanophase bioreactors to catalyze the oxidation of glucose.

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Идентификаторы

DOI: 10.1021/ja027247b

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar