Статья

Short-term effects of troxerutin (vitamin P4) on muscle fatigue and gene expression of <i>Bcl-2</i> and <i>Bax</i> in the hepatic tissue of rats

Mohammad Yasin ZamanianPhysiology-Pharmacology Research Centre and Department of Physiology, Rafsanjan University of Medical Sciences, Rafsanjan, IranAli ShamsizadehPhysiology-Pharmacology Research Centre and Department of Physiology, Rafsanjan University of Medical Sciences, Rafsanjan, IranAli Esmaeili NadimiDepartment of Cardiology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, IranMohammad Reza HajizadehDepartment of Clinical Biochemistry, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, IranFatemeh AllahtavakoliCollege of Science, University of Manitoba, Winnipeg, MB R3T 2N2, CanadaMohammad Reza RahmaniPhysiology-Pharmacology Research Centre and Department of Physiology, Rafsanjan University of Medical Sciences, Rafsanjan, IranAyat KaeidiPhysiology-Pharmacology Research Centre and Department of Physiology, Rafsanjan University of Medical Sciences, Rafsanjan, IranHamidreza Safari KhaleghPhysiology-Pharmacology Research Centre and Department of Physiology, Rafsanjan University of Medical Sciences, Rafsanjan, IranMohammad AllahtavakoliPhysiology-Pharmacology Research Centre and Department of Physiology, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

2017en

ABI

Аннотация

In the current study, the effects of troxerutin (TRX) on muscle fatigue and gene expression of Bcl-2 and Bax in the hepatic tissue of rats was investigated. Forty male Wistar rats were randomly divided into 4 groups and designated as control and TRX treatment at 75 (TRX75), 150 (TRX150), and 300 mg/kg per day (TRX300). The treated groups and control group received TRX and water orally for 7 days. After an exhaustive swimming test on the 7th day, all animals were euthanized immediately and several biochemical parameters related to fatigue and gene expression of Bcl-2 and Bax in the hepatic tissue were measured. Our results showed that the exhaustion swimming time in the TRX300 groups significantly increased 1.2-fold compared with the control group (P < 0.001). TRX300 significantly reduced ALT (P < 0.05) activity and increased liver SOD activity compared with the control group (P < 0.01). Additionally, TRX significantly reduced the liver mRNA expressions of Bax (P < 0.001) and increased the Bcl-2/Bax ratio (P < 0.001) compared with the control group. Based on our data, TRX possesses anti-apoptotic and hepatoprotective action following exhaustive swimming exercise.

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Идентификаторы

DOI: 10.1139/cjpp-2016-0653

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar