Gastric Cancer: Descriptive Epidemiology, Risk Factors, Screening, and Prevention
Parisa KarimiAuthors' Affiliations: 1Johns Hopkins Bloomberg School of Public Health; 2Department of Public Health Analysis, School of Community Health and Policy, Morgan State University, Baltimore; 3Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland; 4Institute for Transitional Epidemiology, Mount Sinai School of Medicine; 5Division of Gastroenterology, Department of Medicine, Mount Sinai Medical Center, New York, New York; and 6Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, IranFarhad IslamiAuthors' Affiliations: 1Johns Hopkins Bloomberg School of Public Health; 2Department of Public Health Analysis, School of Community Health and Policy, Morgan State University, Baltimore; 3Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland; 4Institute for Transitional Epidemiology, Mount Sinai School of Medicine; 5Division of Gastroenterology, Department of Medicine, Mount Sinai Medical Center, New York, New York; and 6Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, IranSharmila AnandasabapathyAuthors' Affiliations: 1Johns Hopkins Bloomberg School of Public Health; 2Department of Public Health Analysis, School of Community Health and Policy, Morgan State University, Baltimore; 3Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland; 4Institute for Transitional Epidemiology, Mount Sinai School of Medicine; 5Division of Gastroenterology, Department of Medicine, Mount Sinai Medical Center, New York, New York; and 6Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, IranNeal D. FreedmanAuthors' Affiliations: 1Johns Hopkins Bloomberg School of Public Health; 2Department of Public Health Analysis, School of Community Health and Policy, Morgan State University, Baltimore; 3Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland; 4Institute for Transitional Epidemiology, Mount Sinai School of Medicine; 5Division of Gastroenterology, Department of Medicine, Mount Sinai Medical Center, New York, New York; and 6Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, IranFarin KamangarAuthors' Affiliations: 1Johns Hopkins Bloomberg School of Public Health; 2Department of Public Health Analysis, School of Community Health and Policy, Morgan State University, Baltimore; 3Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland; 4Institute for Transitional Epidemiology, Mount Sinai School of Medicine; 5Division of Gastroenterology, Department of Medicine, Mount Sinai Medical Center, New York, New York; and 6Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
2014en
ABI
Аннотация
Less than a century ago, gastric cancer was the most common cancer in the United States and perhaps throughout the world. Despite its worldwide decline in incidence over the past century, gastric cancer remains a major killer across the globe. This article reviews the epidemiology, screening, and prevention of gastric cancer. We first discuss the descriptive epidemiology of gastric cancer, including its incidence, survival, mortality, and trends over time. Next, we characterize the risk factors for gastric cancer, both environmental and genetic. Serologic markers and histological precursor lesions of gastric cancer and early detection of gastric cancer using these markers are reviewed. Finally, we discuss prevention strategies and provide suggestions for further research.
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