Обзорная статья

Exosomal miRNAs: Novel Players in Viral Infection

Javid Sadri NahandDepartment of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, IranMaryam Mahjoubin‐TehranDepartment of Medical Biotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranMohsen MoghoofeiDepartment of Microbiology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, IranMohammad Hossein PourhanifehHalal Research Center of IRI, FDA, Tehran, IranHamid Reza MirzaeiDepartment of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, IranZatollah AsemiResearch Center for Biochemistry & Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, IranAlireza KhatamiDepartment of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, IranFarah Bokharaei‐SalimDepartment of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, IranHamed MirzaeiFax: +98 31 55540022Michael R. HamblinWellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, 40 Blossom Street, Boston, MA02114, USA

2020en

ABI

Аннотация

Exosomes are secreted nanovesicles that are able to transfer their cargo (such as miRNAs) between cells. To determine to what extent exosomes and exosomal miRNAs are involved in the pathogenesis, progression and diagnosis of viral infections. The scientific literature (PubMed and Google Scholar) was searched from 1970 to 2019. The complex biogenesis of exosomes and miRNAs was reviewed. Exosomes contain both viral and host miRNAs that can be used as diagnostic biomarkers for viral diseases. Viral proteins can alter miRNAs, and conversely miRNAs can alter the host response to viral infections in a positive or negative manner. It is expected that exosomal miRNAs will be increasingly used for diagnosis, monitoring and even treatment of viral infections.

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Идентификаторы

DOI: 10.2217/epi-2019-0192

Цитирования и источники

Цитирований: 6Использованных источников: 0

Показатели — AkademScholar