Aldehyde-functional thermoresponsive diblock copolymer worm gels exhibit strong mucoadhesion
Emma E. BrothertonDainton Building, Department of Chemistry, University of Sheffield, Brook Hill, Sheffield, South Yorkshire, S3 7HF, UKThomas J. NealDainton Building, Department of Chemistry, University of Sheffield, Brook Hill, Sheffield, South Yorkshire, S3 7HF, UKDaulet B. KaldybekovDepartment of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty 050040, KazakhstanMark J. SmallridgeGEO Specialty Chemicals, Hythe, Southampton, Hampshire SO45 3ZG, UKVitaliy V. KhutoryanskiySchool of Pharmacy, University of Reading, Whiteknights, PO Box 224, Reading, Berkshire, RG6 6DX, UKSteven P. ArmesDainton Building, Department of Chemistry, University of Sheffield, Brook Hill, Sheffield, South Yorkshire, S3 7HF, UK
2022en
ABI
Аннотация
-diol molar ratio. These aldehyde-functional worm gels are evaluated in terms of their mucoadhesion performance with the aid of a fluorescence microscopy-based assay. Using porcine urinary bladder mucosa as a model substrate, we demonstrate that these worm gels offer a comparable degree of mucoadhesion to that afforded by chitosan, which is widely regarded to be a 'gold standard' positive control in this context. The optimum degree of aldehyde functionality is approximately 30%: lower degrees of functionalization lead to weaker mucoadhesion, whereas higher values compromise the desirable thermoresponsive behavior of these worm gels.
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