Обзорная статья

The convergence of traditional and digital biomarkers through AI-assisted biosensing: A new era in translational diagnostics?

Sagar S. AryaDepartment of Biomedical Engineering, Khalifa University of Science and Technology, P.O. Box 127788, Abu Dhabi, United Arab EmiratesSofia B. DiasDepartment of Biomedical Engineering, Khalifa University of Science and Technology, P.O. Box 127788, Abu Dhabi, United Arab Emirates; Interdisciplinary Center for Human Performance, Faculdade de Motricidade Humana, Universidade de Lisboa, Portugal. Electronic address: [email protected]Herbert F. JelinekDepartment of Biomedical Engineering, Khalifa University of Science and Technology, P.O. Box 127788, Abu Dhabi, United Arab Emirates; Healthcare Engineering Innovation Center (HEIC), Khalifa University of Science and Technology, P O Box 127788, Abu Dhabi, United Arab EmiratesLeontios J. HadjileontiadisDepartment of Biomedical Engineering, Khalifa University of Science and Technology, P.O. Box 127788, Abu Dhabi, United Arab Emirates; Healthcare Engineering Innovation Center (HEIC), Khalifa University of Science and Technology, P O Box 127788, Abu Dhabi, United Arab Emirates; Department of Electrical and Computer Engineering, Aristotle University of Thessaloniki, GR, 54124, Thessaloniki, GreeceAnna‐Maria PappaDepartment of Biomedical Engineering, Khalifa University of Science and Technology, P.O. Box 127788, Abu Dhabi, United Arab Emirates; Healthcare Engineering Innovation Center (HEIC), Khalifa University of Science and Technology, P O Box 127788, Abu Dhabi, United Arab Emirates; Department of Chemical Engineering and Biotechnology, Cambridge University, Cambridge, UK. Electronic address: [email protected]

2023en

ABI

Аннотация

Advances in consumer electronics, alongside the fields of microfluidics and nanotechnology have brought to the fore low-cost wearable/portable smart devices. Although numerous smart devices that track digital biomarkers have been successfully translated from bench-to-bedside, only a few follow the same fate when it comes to track traditional biomarkers. Current practices still involve laboratory-based tests, followed by blood collection, conducted in a clinical setting as they require trained personnel and specialized equipment. In fact, real-time, passive/active and robust sensing of physiological and behavioural data from patients that can feed artificial intelligence (AI)-based models can significantly improve decision-making, diagnosis and treatment at the point-of-procedure, by circumventing conventional methods of sampling, and in person investigation by expert pathologists, who are scarce in developing countries. This review brings together conventional and digital biomarker sensing through portable and autonomous miniaturized devices. We first summarise the technological advances in each field vs the current clinical practices and we conclude by merging the two worlds of traditional and digital biomarkers through AI/ML technologies to improve patient diagnosis and treatment. The fundamental role, limitations and prospects of AI in realizing this potential and enhancing the existing technologies to facilitate the development and clinical translation of "point-of-care" (POC) diagnostics is finally showcased.

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Идентификаторы

DOI: 10.1016/j.bios.2023.115387

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar