Evaluating the effect of 20-hydroxyecdysone (20HE) on mechanistic target of rapamycin complex 1 (mTORC1) signaling in the skeletal muscle and liver of rats
Tracy G. AnthonyDepartment of Nutritional Sciences, Rutgers University, New Brunswick, NJ 08901, USAEmily T. MirekDepartment of Nutritional Sciences, Rutgers University, New Brunswick, NJ 08901, USAAlbert BargoudDepartment of Nutritional Sciences, Rutgers University, New Brunswick, NJ 08901, USALindsey Phillipson‐WeinerDepartment of Nutritional Sciences, Rutgers University, New Brunswick, NJ 08901, USAChristopher M. DeOliveiraDepartment of Nutritional Sciences, Rutgers University, New Brunswick, NJ 08901, USABerish B. WetsteinDepartment of Nutritional Sciences, Rutgers University, New Brunswick, NJ 08901, USABrittany L. GrafDepartment of Plant Biology and Pathology, Rutgers University, New Brunswick, NJ 08901, USAPeter KühnDepartment of Plant Biology and Pathology, Rutgers University, New Brunswick, NJ 08901, USAIlya RaskinDepartment of Plant Biology and Pathology, Rutgers University, New Brunswick, NJ 08901, USA
2015en
ABI
Аннотация
Phytoecdysteroids such as 20-hydroxyecdysone (20HE) are nutritional supplements marketed as enhancers of lean body mass. In this study the impact of 20HE ingestion on protein kinase B/Akt-mechanistic target of rapamycin complex 1 signaling in the skeletal muscle and liver of male rats was found to be limited. Bioavailability of 20HE, whether consumed alone or with leucine, also remained low at all doses ingested. Additional work is necessary to clarify 20HE mechanism of action in vivo.
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