Обзорная статья

Clinical characteristics of children with COVID-19: a rapid review and meta-analysis

on behalf of COVID-19 Evidence and Recommendations Working GroupEvidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, ChinaZijun WangEvidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, ChinaQi ZhouThe First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, ChinaChenglin WangChongqing Key Laboratory of Pediatrics, Chongqing 400014, ChinaQianling ShiThe First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, ChinaShuya LuChinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu 610072, ChinaYanfang MaEvidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, ChinaXufei LuoSchool of Public Health, Lanzhou University, Lanzhou 730000, ChinaYangqin XunEvidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, ChinaWeiguo LiChongqing Key Laboratory of Pediatrics, Chongqing 400014, ChinaMuna BaskotaChongqing Key Laboratory of Pediatrics, Chongqing 400014, ChinaYinmei YangChongqing Key Laboratory of Pediatrics, Chongqing 400014, ChinaHui ZhaiChongqing Key Laboratory of Pediatrics, Chongqing 400014, ChinaToshio FukuokaAdvisory Committee in Cochrane Japan, Tokyo, JapanHyeong Sik AhnDepartment of Preventive Medicine, Korea University College of Medicine, Seoul, KoreaMyeong Soo LeeKorea Institute of Oriental Medicine, Daejeon, KoreaZhengxiu LuoDepartment of Respiratory Medicine, Children's Hospital of Chongqing Medical University, Chongqing 400014, ChinaEnmei LiuChongqing Key Laboratory of Pediatrics, Chongqing 400014, ChinaYaolong ChenChinese GRADE Center, Lanzhou 730000, China

2020en

ABI

Аннотация

BACKGROUND: Most guidelines on COVID-19 published so far include recommendations for patients regardless of age. Clinicians need a more accurate understanding of the clinical characteristics of children with COVID-19. METHODS: We searched studies reporting clinical characteristics in children with COVID-19 published until March 31, 2020. We screened the literature, extracted the data and evaluated the risk of bias and quality of evidence of the included studies. We combined some of the outcomes (symptoms) in a single-arm meta-analysis using a random-effects model. RESULTS: Our search retrieved 49 studies, including 25 case reports, 23 case series and one cohort study, with a total of 1,667 patients. Our meta-analysis showed that most children with COVID-19 have mild symptoms. Eighty-three percent of the children were within family clusters of cases, and 19% had no symptoms. At least 7% with digestive symptoms. The main symptoms of children were fever [48%, 95% confidence interval (CI): 39%, 56%] and cough (39%, 95% CI: 30%, 48%). The lymphocyte count was below normal level in only 15% (95% CI: 8%, 22%) of children which is different from adult patients. 66% (95% CI: 55%, 77%) of children had abnormal findings in CT imaging. CONCLUSIONS: Most children with COVID-19 have only mild symptoms, and many children are asymptomatic. Fever and cough are the most common symptoms in children. Vomiting and diarrhea were not common in children. The lymphocyte count is usually within the normal range in children.

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Идентификаторы

DOI: 10.21037/atm-20-3302

Цитирования и источники

Цитирований: 3Использованных источников: 0

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