Обзорная статья

Resveratrol: A Double-Edged Sword in Health Benefits

Bahare SalehiMedical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran 88777539, IranAbhay Prakash MishraDepartment of Pharmaceutical Chemistry, H. N. B. Garhwal (A Central) University, Srinagar Garhwal 246174, Uttarakhand, IndiaManisha NigamDepartment of Biochemistry, H. N. B. Garhwal (A Central) University, Srinagar Garhwal 246174, Uttarakhand, IndiaBilge ŞenerGazi University Faculty of Pharmacy Department of Pharmacognosy, Ankara 06330, TurkeyMehtap KılıçGazi University Faculty of Pharmacy Department of Pharmacognosy, Ankara 06330, TurkeyMehdi Sharifi‐RadDepartment of Medical Parasitology, Zabol University of Medical Sciences, Zabol 61663335, IranPatrick Valère Tsouh FokouAntimicrobial and Biocontrol Agents Unit, Department of Biochemistry, Faculty of Science, University of Yaounde 1, Ngoa Ekelle, Annex Fac. Sci, P.O. Box. 812, Yaounde-CameroonNatália MartinsFaculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, Porto 4200-319, PortugalJavad Sharifi‐RadDepartment of Chemistry, Richardson College for the Environmental Science Complex, The University of Winnipeg, Winnipeg, MB R3B 2G3, Canada

2018en

ABI

Аннотация

Resveratrol (3,5,4'-trihydroxy-trans-stilbene) belongs to polyphenols' stilbenoids group, possessing two phenol rings linked to each other by an ethylene bridge. This natural polyphenol has been detected in more than 70 plant species, especially in grapes' skin and seeds, and was found in discrete amounts in red wines and various human foods. It is a phytoalexin that acts against pathogens, including bacteria and fungi. As a natural food ingredient, numerous studies have demonstrated that resveratrol possesses a very high antioxidant potential. Resveratrol also exhibit antitumor activity, and is considered a potential candidate for prevention and treatment of several types of cancer. Indeed, resveratrol anticancer properties have been confirmed by many in vitro and in vivo studies, which shows that resveratrol is able to inhibit all carcinogenesis stages (e.g., initiation, promotion and progression). Even more, other bioactive effects, namely as anti-inflammatory, anticarcinogenic, cardioprotective, vasorelaxant, phytoestrogenic and neuroprotective have also been reported. Nonetheless, resveratrol application is still being a major challenge for pharmaceutical industry, due to its poor solubility and bioavailability, as well as adverse effects. In this sense, this review summarized current data on resveratrol pharmacological effects.

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Идентификаторы

DOI: 10.3390/biomedicines6030091

Цитирования и источники

Цитирований: 6Использованных источников: 0

Показатели — AkademScholar