Статья

Solubilities of acetaminophen in supercritical carbon dioxide with and without menthol cosolvent: Measurement and correlation

J. Karimi SabetDepartment of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, P.O. Box 11155-8639, IranCyrus GhotbiDepartment of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, P.O. Box 11155-8639, IranFarid Abedin DorkooshDepartment of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 11365-8639, IranAlberto StrioloSchool of Chemical, Biological and Materials Engineering, The University of Oklahoma, Sarkeys Energy Centre T-235, Norman, OK 73019, USA

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Аннотация

The solubility of acetaminophen in SuperCritical-Carbon Dioxide (SC- CO2) with and without menthol as a cosolvent was measured at various temperatures (313, 328 and 343) K, and within pressures ranging from (10 to 25) MPa. It should be stated that the cosolvent, menthol, has chiral isomers with different melting points. Therefore, the effects of both menthol (I) with a lower melting point and menthol (II) with a higher melting point, as cosolvents on the solubility of acetaminophen in SC- CO2, were studied. The experimental data collected in this work were obtained using a static flow apparatus. The experiments were replicated at least three times and the data reported are the average of the replicas. Finally, the data reduction for the solubility of acetaminophen in SC- CO2 in the presence and in the absence of menthol (I) and menthol (II), were correlated, using the semi-empirical equations proposed by Chrastil and Mendez-Santiago & Teja. The results obtained from these equations were in good agreement with the experimental data.

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Идентификаторы

DOI: 10.1016/j.scient.2011.11.046

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