Статья

Solubility measurement of verapamil for the preparation of developed nanomedicines using supercritical fluid

Nadia EsfandiariDepartment of Chemical Engineering, Marvdasht Branch, Islamic Azad University, Marvdasht, IranNedasadat Saadati ArdestaniNanotechnology Research Center, Research Institute of Petroleum Industry (RIPI), P.O. Box 14857-336, Tehran, IranRatna Surya AlwiNational Research and Innovation Agency (BRIN), Jl. Raya Jakarta-Bogor KM 46, Cibinong, IndonesiaAdrián RojasCenter for the Development of Nanoscience and Nanotechnology (CEDENNA), 9170124, Santiago, ChileChandrasekhar GarlapatiDepartment of Chemical Engineering, Pondicherry Technological University, Puducherry, 605014, India. [email protected]Seyed Ali SajadianDepartment of Chemical Engineering, Faculty of Engineering, University of Kashan, Kashan, 87317-53153, Iran. [email protected]

2023en

ABI

Аннотация

Abstract A static method is employed to determine the solubilities of verapamil in supercritical carbon dioxide (SC-CO 2 ) at temperatures between 308 and 338 K and pressures between 12 and 30 MPa. The solubility of verapamil in SC-CO 2 expressed as mole fraction are in the range of 3.6 × 10 –6 to 7.14 × 10 –5 . Using four semi-empirical density-based models, the solubility data are correlated: Chrastil, Bartle, Kumar–Johnston (K–J), and Mendez-Santiago and Teja (MST), two equations of state (SRK and PC-SAFT EoS), expanded liquid models (modified Wilson's models), and regular solution model. The obtained results indicated that the regular solution and PC-SAFT models showed the most noteworthy exactness with AARD% of 1.68 and 7.45, respectively. The total heat, vaporization heat, and solvation heat of verapamil are calculated at 39.62, 60.03, and − 20.41 kJ/mol, respectively. Regarding the poor solubility of verapamil in SC-CO 2 , supercritical anti-solvent methods can be an appropriate choice to produce fine particles of this drug.

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Идентификаторы

DOI: 10.1038/s41598-023-44280-7

Цитирования и источники

Цитирований: 3Использованных источников: 0

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