Обзорная статья

Characteristics of the cancer stem cell niche and therapeutic strategies

Feng JuGeneral, Visceral and Cancer Surgery, University Hospital of Cologne, Kerpener Straße 62, Cologne, GermanyManar AtyahDepartment of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, ChinaNellie HorstmannGeneral, Visceral and Cancer Surgery, University Hospital of Cologne, Kerpener Straße 62, Cologne, GermanySheraz GulFraunhofer Cluster of Excellence for Immune-Mediated Diseases CIMD, 22525, Hamburg, GermanyRazi VagoAvram and Stella Goldstein-Goren, Department of Biotechnology Engineering, Ben-Gurion University of the Negev, Beer-Sheva, IsraelChristiane J. BrunsGeneral, Visceral and Cancer Surgery, University Hospital of Cologne, Kerpener Straße 62, Cologne, GermanyYue ZhaoGeneral, Visceral and Cancer Surgery, University Hospital of Cologne, Kerpener Straße 62, Cologne, Germany. [email protected]Qiongzhu DongInstitute of Fudan-Minhang Academic Health System, Minhang Hospital, Fudan University, Shanghai, 201199, ChinaNing RenDepartment of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China. [email protected]

2022en

ABI

Аннотация

Distinct regions harboring cancer stem cells (CSCs) have been identified within the microenvironment of various tumors, and as in the case of their healthy counterparts, these anatomical regions are termed "niche." Thus far, a large volume of studies have shown that CSC niches take part in the maintenance, regulation of renewal, differentiation and plasticity of CSCs. In this review, we summarize and discuss the latest findings regarding CSC niche morphology, physical terrain, main signaling pathways and interactions within them. The cellular and molecular components of CSCs also involve genetic and epigenetic modulations that mediate and support their maintenance, ultimately leading to cancer progression. It suggests that the crosstalk between CSCs and their niche plays an important role regarding therapy resistance and recurrence. In addition, we updated diverse therapeutic strategies in different cancers in basic research and clinical trials in this review. Understanding the complex heterogeneity of CSC niches is a necessary pre-requisite for designing superior therapeutic strategies to target CSC-specific factors and/or components of the CSC niche.

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Идентификаторы

DOI: 10.1186/s13287-022-02904-1

Цитирования и источники

Цитирований: 3Использованных источников: 0

Показатели — AkademScholar