Alginate/pectin dressing with niosomal mangosteen extract for enhanced wound healing: evaluating skin irritation by structure-activity relationship
Philaslak PoopromminSchool of Medicine, Walailak University, Nakhon Si Thammarat 80160, ThailandChawan ManasponBiomedical Engineering Institute, Chiang Mai University, Chiang Mai 50200, ThailandAnupma DwivediFaculty of Pharmacy, Charles University, Hradec Králové, Czech RepublicAnisha MazumderFaculty of Pharmacy, Charles University, Hradec Králové, Czech RepublicSurat SangkaewSchool of Medicine, Walailak University, Nakhon Si Thammarat 80160, ThailandSmith WanmasaeSchool of Allied Health Sciences, Walailak University, Nakhon Si Thammarat 80160, ThailandJitbanjong TangpongResearch Excellence Center for Innovation and Health Products (RECIHP), Walailak University, Nakhon Si Thammarat 80160, ThailandTassanee OngtanasupSchool of Medicine, Walailak University, Nakhon Si Thammarat 80160, ThailandKomgrit EawsakulResearch Excellence Center for Innovation and Health Products (RECIHP), Walailak University, Nakhon Si Thammarat 80160, Thailand
2022en
ABI
Аннотация
crosslinking were 867 wt% and 1,025 wt%, respectively, after 30 min. These results suggested that a medium dose (15 mg) of niosomal ME incorporated in a hydrogel film provided better bacterial inhibition, cell migration, and cell adhesion in an in vitro model. Additionally, no toxicity was observed in the fibroblasts and red blood cells. Therefore, given the above-mentioned advantages, this product can be a promising candidate for wound dressing applications.
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