Обзорная статья

Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer

Javad Sharifi‐RadPhytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranCristina QuispeFacultad de Ciencias de la Salud, Universidad Arturo Prat, Iquique, ChileZhazira MukazhanovaDepartment of Natural Sciences and Technologies, Sarsen Amanzholov East Kazakhstan State University, Ust-Kamenogorsk, KazakhstanEwa KnutChair and Department of Pharmaceutical Botany, Faculty of Pharmacy, Jagiellonian University, Medical College, Kraków, PolandAknur TurgumbayevaAl-Farabi Kazakh National University, Higher School of Medicine, Almaty, KazakhstanAliya KipchakbayevaFaculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, KazakhstanGulnaz SeitimovaFaculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, KazakhstanMohamad Fawzi MahomoodallyDepartment of Health Sciences, Faculty of Medicine and Health Sciences, University of Mauritius, Réduit, MauritiusDevina LobineDepartment of Health Sciences, Faculty of Medicine and Health Sciences, University of Mauritius, Réduit, MauritiusAaron KoayTrinity College Dublin, NatPro (Natural Products Research Centre), School of Pharmacy and Pharmaceutical Science, Dublin, IrelandJinfan WangTrinity College Dublin, NatPro (Natural Products Research Centre), School of Pharmacy and Pharmaceutical Science, Dublin, IrelandHelen SheridanTrinity College Dublin, NatPro (Natural Products Research Centre), School of Pharmacy and Pharmaceutical Science, Dublin, IrelandGerardo Leyva‐GómezDepartamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico City, MexicoMaría Luisa Del Prado-AudeloDepartamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico City, MexicoHernán CortésLaboratorio de Medicina Genómica, Departamento de Genética, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Ciudad de México, Mexico City, MexicoAntonio RescignoDepartment of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, Cagliari, ItalyPaolo ZuccaDepartment of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, Cagliari, ItalyOksana SytarDepartment of Plant Biology, Institute of Biology, Taras Shevchenko National University of Kyiv, Kyiv, UkraineMuhammad ImranUniversity Institute of Diet and Nutritional Sciences, The University of Lahore, Lahore, PakistanCélia F. RodriguesLaboratory for Process Engineering, Environment, Biotechnology and Energy-Department of Chemical Engineering, Faculty of Engineering, University of Porto, Porto, PortugalNatália MartinsFaculty of Medicine, University of Porto, Porto, PortugalHalina EkiertChair and Department of Pharmaceutical Botany, Faculty of Pharmacy, Jagiellonian University, Medical College, Kraków, PolandManoj KumarChemical and Biochemical Processing Division, ICAR - Central Institute for Research on Cotton Technology, Mumbai, IndiaAhmad Faizal Abdull RazisDepartment of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, Selangor, MalaysiaSunusi UsmanDepartment of Biochemistry, Bayero University Kano, Kano, NigeriaRamla Muhammad KamalDepartment of Pharmacology, Federal University Dutse, Dutse, NigeriaAgnieszka SzopaChair and Department of Pharmaceutical Botany, Faculty of Pharmacy, Jagiellonian University, Medical College, Kraków, Poland

2021en

ABI

Аннотация

Resveratrol is a polyphenolic stilbene derivative widely present in grapes and red wine. Broadly known for its antioxidant effects, numerous studies have also indicated that it exerts anti-inflammatory and antiaging abilities and a great potential in cancer therapy. Regrettably, the oral administration of resveratrol has pharmacokinetic and physicochemical limitations such as hampering its effects so that effective administration methods are demanding to ensure its efficiency. Thus, the present review explores the published data on the application of resveratrol nanoformulations in cancer therapy, with the use of different types of nanodelivery systems. Mechanisms of action with a potential use in cancer therapy, negative effects, and the influence of resveratrol nanoformulations in different types of cancer are also highlighted. Finally, the toxicological features of nanoresveratrol are also discussed.

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Идентификаторы

DOI: 10.3389/fmolb.2021.649395

Цитирования и источники

Цитирований: 3Использованных источников: 0

Показатели — AkademScholar