Обзорная статья

T Regulatory Cells and Priming the Suppressive Tumor Microenvironment

Christina PaluskieviczDepartment of Surgery, University of Maryland School of Medicine, Baltimore, MD, United StatesXuefang CaoDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, United StatesReza AbdiDivision of Renal Medicine, Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United StatesPan ZhengDepartment of Surgery, University of Maryland School of Medicine, Baltimore, MD, United StatesYang LiuDepartment of Surgery, University of Maryland School of Medicine, Baltimore, MD, United StatesJonathan S. BrombergCenter for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD, United States

2019en

ABI

Аннотация

Treg play a central role in maintenance of self tolerance and homeostasis through suppression of self-reactive T cell populations. In addition to that role, Treg also survey cancers and suppress anti-tumor immune responses. Thus, understanding the unique attributes of Treg-tumor interactions may permit control of this pathologic suppression without interfering with homeostatic self-tolerance. This review will define the unique role of Treg in cancer growth, and the ways by which Treg inhibit a robust anti-tumor immune response. There will be specific focus placed on Treg homing to the tumor microenvironment (TME), TME formation of induced Treg (iTreg), mechanisms of suppression that underpin cancer immune escape, and trophic nonimmunologic effects of Treg on tumor cells.

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Идентификаторы

DOI: 10.3389/fimmu.2019.02453

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar