Статья

Antihypertensive Effects of Artemisia scoparia Waldst in Spontaneously Hypertensive Rats and Identification of Angiotensin I Converting Enzyme Inhibitors

Jeong‐Yong ChoDepartment of Food Biotechnology and Solar Salt Research Center, Mokpo National University, Jeonnam 534-729, KoreaKyung‐Hee ParkDepartment of Food Biotechnology and Solar Salt Research Center, Mokpo National University, Jeonnam 534-729, KoreaDo Yeon HwangDepartment of Food Biotechnology and Solar Salt Research Center, Mokpo National University, Jeonnam 534-729, KoreaSaoraya ChanmuangDepartment of Food Biotechnology and Solar Salt Research Center, Mokpo National University, Jeonnam 534-729, KoreaLily JaiswalDepartment of Food Biotechnology and Solar Salt Research Center, Mokpo National University, Jeonnam 534-729, KoreaYang-Kyun ParkDepartment of Food Biotechnology and Solar Salt Research Center, Mokpo National University, Jeonnam 534-729, KoreaSunyoung ParkDepartment of Food Biotechnology and Solar Salt Research Center, Mokpo National University, Jeonnam 534-729, KoreaSo-Young KimDivision of Functional Food & Nutrition, National Academy of Agricultural Sciences, Rural Development Administration (RDA), Jeonbuk 560-500, KoreaHaeng-Ran KimDivision of Functional Food & Nutrition, National Academy of Agricultural Sciences, Rural Development Administration (RDA), Jeonbuk 560-500, KoreaJae‐Hak MoonDepartment of Food Science & Technology, and Functional Food Research Center, Chonnam National University, Gwangju 500-757, KoreaKyung‐Sik HamDepartment of Food Biotechnology and Solar Salt Research Center, Mokpo National University, Jeonnam 534-729, Korea

2015en

ABI

Аннотация

We investigated the antihypertensive effects of Artemisia scoparia (AS) in spontaneously hypertensive rats (SHR). The rats were fed diets containing 2% (w/w) hot water extracts of AS aerial parts for 6 weeks. The AS group had significantly lower systolic and diastolic blood pressure levels than the control group. The AS group also had lower angiotensin I converting enzyme (ACE) activity and angiotensin II content in serum compared to the control group. The AS group showed higher vascular endothelial growth factor and lower ras homolog gene family member A expression levels in kidney compared to the control group. The AS group had significantly lower levels of plasma lipid oxidation and protein carbonyls than the control group. One new and six known compounds were isolated from AS by guided purification. The new compound was determined to be 4'-O-β-D-glucopyranoyl (E)-4-hydroxy-3-methylbut-2-enyl benzoate, based on its nuclear magnetic resonance and electrospray ionization-mass spectroscopy data.

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Идентификаторы

DOI: 10.3390/molecules201119657

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar