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Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

Manli WangState Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, ChinaRuiyuan CaoLeike ZhangState Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, ChinaXing‐Lou YangState Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, ChinaJia LiuState Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, ChinaMingyue XuState Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, ChinaZhengli ShiState Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, ChinaZhìhóng HúState Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, China. [email protected]Wu ZhongNational Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, 100850, Beijing, China. [email protected]Gengfu XiaoState Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, China. [email protected]
2020en
ABI

Аннотация

In December 2019, a novel pneumonia caused by a previously
\nunknown pathogen emerged in Wuhan, a city of 11 million
\npeople in central China. The initial cases were linked to
\nexposures in a seafood market in Wuhan.1 As of January 27,
\n2020, the Chinese authorities reported 2835 confirmed cases in
\nmainland China, including 81 deaths. Additionally, 19 confirmed
\ncases were identified in Hong Kong, Macao and Taiwan, and 39
\nimported cases were identified in Thailand, Japan, South Korea,
\nUnited States, Vietnam, Singapore, Nepal, France, Australia
\nand Canada. The pathogen was soon identified as a novel
\ncoronavirus (2019-nCoV), which is closely related to sever acute
\nrespiratory syndrome CoV (SARS-CoV).2 Currently, there is no
\nspecific treatment against the new virus. Therefore, identifying
\neffective antiviral agents to combat the disease is urgently
\nneeded.

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DOI
10.1038/s41422-020-0282-0

Цитирования и источники

Цитирований: 4Использованных источников: 0
Показатели — AkademScholar