Статья

Dextran phosphate stabilized selenium nanoparticles for creating a prolonged-release form of doxorubicin

Uladzislau E. AharodnikauResearch Institute of Physical and Chemical Problems of the Belarusian State University; Unitary Enterprise “UNITEKHPROM BSU”; Belarusian State UniversityAliaksandra V YedchykUnitary Enterprise “UNITEKHPROM BSU”; Belarusian State UniversityYu. I. PristromovaResearch Institute of Physical and Chemical Problems of the Belarusian State University; Unitary Enterprise “UNITEKHPROM BSU”; Belarusian State UniversityAnastasiya V BaranouskayaUnitary Enterprise “UNITEKHPROM BSU”; Belarusian State UniversityAnhelina G KarcheuskayaUnitary Enterprise “UNITEKHPROM BSU”; Belarusian State UniversityKhaydar E. YunusovInstitute of Chemistry and Physics of Polymers of the Academy of Sciences of the Republic of UzbekistanA. A. SarymsakovInstitute of Chemistry and Physics of Polymers of the Academy of Sciences of the Republic of UzbekistanС. Ш. РашидоваInstitute of Chemistry and Physics of Polymers of the Academy of Sciences of the Republic of UzbekistanV. А. AlinovskayaResearch Institute of Physical and Chemical Problems of the Belarusian State UniversityPavel M. BychkovskyResearch Institute of Physical and Chemical Problems of the Belarusian State University; Unitary Enterprise “UNITEKHPROM BSU”T. L. YurkshtovichResearch Institute of Physical and Chemical Problems of the Belarusian State University; Unitary Enterprise “UNITEKHPROM BSU”

Proceedings of the National Academy of Sciences of Belarus Chemical Seriesjournal2025en

ABI

Аннотация

Nanobiotechnology is an actively developing field of science, which finds application in cancer therapy, molecular diagnostics and molecular imaging. In this work, selenium nanoparticles were successfully obtained by chemical reduction of selenite ions with ascorbic acid in dextran phosphate (DP) solutions, which was used as a stabilizer. It has been found that dextran phosphate coated nanoparticles are stable during storage for 3 days. Sorption of the antitumor substance doxorubicin was studied in the concentration range from 0.1 mg/ml to 1 mg/ml. A significant prolongation of cytostatic release from stabilized nanoparticles was shown. Selenium nanoparticles coated with water-soluble DP can be used to create broad-spectrum drugs, in particular, antitumor drugs that compensate for selenium deficiency in the body.

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Темы

Selenium in Biological Systems Carbon and Quantum Dots Applications Thallium and Germanium Studies

Идентификаторы

DOI: 10.29235/1561-8331-2025-61-1-30-40

Цитирования и источники

Цитирований: 1 Использованных источников: 19

Показатели — AkademScholar