Статья

Pulmonary toxicity of Fe2O3, ZnFe2O4, NiFe2O4 and NiZnFe4O8 nanomaterials: Inflammation and DNA strand breaks

Niels HadrupNational Research Centre for the Working Environment (NFA), 105 Lersø Parkallé, Copenhagen Ø, Denmark. Electronic address: [email protected]Anne Thoustrup SaberNational Research Centre for the Working Environment (NFA), 105 Lersø Parkallé, Copenhagen Ø, Denmark. Electronic address: [email protected]Zdenka O. KyjovskaNational Research Centre for the Working Environment (NFA), 105 Lersø Parkallé, Copenhagen Ø, Denmark. Electronic address: [email protected]Nicklas Raun JacobsenNational Research Centre for the Working Environment (NFA), 105 Lersø Parkallé, Copenhagen Ø, Denmark. Electronic address: [email protected]Minnamari VippolaMaterials Science and Environmental Engineering, Tampere University, P.O.Box 589, 33014 Tampere University, Finland. Electronic address: [email protected]Essi SarlinMaterials Science and Environmental Engineering, Tampere University, P.O.Box 589, 33014 Tampere University, Finland. Electronic address: [email protected]Yaobo DingComprehensive Pneumology Center, Member of the German Center for Lung Research, Max-Lebsche-Platz 31, 81377 Munich, Germany; Institute of Lung Biology and Disease, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany. Electronic address: [email protected]Otmar SchmidComprehensive Pneumology Center, Member of the German Center for Lung Research, Max-Lebsche-Platz 31, 81377 Munich, Germany; Institute of Lung Biology and Disease, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany. Electronic address: [email protected]Håkan WallinNational Institute of Occupational Health, Oslo, Norway. Electronic address: [email protected]Keld Alstrup JensenNational Research Centre for the Working Environment (NFA), 105 Lersø Parkallé, Copenhagen Ø, Denmark. Electronic address: [email protected]Ulla VogelNational Research Centre for the Working Environment (NFA), 105 Lersø Parkallé, Copenhagen Ø, Denmark; Department of Health Technology, Danish Technical University (DTU), DK-2800 Kgs. Lyngby, Denmark. Electronic address: [email protected]

2019en

ABI

Аннотация

Exposure to metal oxide nanomaterials potentially occurs at the workplace. We investigated the toxicity of two Fe-oxides: Fe2O3 nanoparticles and nanorods; and three MFe2O4 spinels: NiZnFe4O8, ZnFe2O4, and NiFe2O4 nanoparticles. Mice were dosed 14, 43 or 128 μg by intratracheal instillation. Recovery periods were 1, 3, or 28 days. Inflammation – neutrophil influx into bronchoalveolar lavage (BAL) fluid – occurred for Fe2O3 rods (1 day), ZnFe2O4 (1, 3 days), NiFe2O4 (1, 3, 28 days), Fe2O3 (28 days) and NiZnFe4O8 (28 days). Conversion of mass-dose into specific surface-area-dose showed that inflammation correlated with deposited surface area and consequently, all these nanomaterials belong to the so-called low-solubility, low-toxicity class. Increased levels of DNA strand breaks were observed for both Fe2O3 particles and rods, in BAL cells three days post-exposure. To our knowledge, this is, besides magnetite (Fe3O4), the first study of the pulmonary toxicity of MFe2O4 spinel nanomaterials.

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Идентификаторы

DOI: 10.1016/j.etap.2019.103303

Цитирования и источники

Цитирований: 4Использованных источников: 0

Показатели — AkademScholar