Обзорная статья

Chitosan-Based Nanoparticles as Effective Drug Delivery Systems—A review

Karolina JafernikChair and Department of Pharmaceutical Botany, Jagiellonian University, Medical College, Medyczna 9, 30-688 Kraków, PolandAgata ŁadniakDepartment of Chemistry, Institute of Biology Sciences, Faculty of Medicine, The John Paul II Catholic University of Lublin, Konstantynów 1J, 20-708 Lublin, PolandEliza BlicharskaDepartment of Analytical Chemistry, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, PolandKatarzyna CzarnekInstitute of Health Sciences, Faculty of Medicine, The John Paul II Catholic University of Lublin, Konstantynów 1H, 20-708 Lublin, PolandHalina EkiertChair and Department of Pharmaceutical Botany, Jagiellonian University, Medical College, Medyczna 9, 30-688 Kraków, PolandAgnieszka Ewa WiącekDepartment of Interfacial Phenomena, Institute of Chemical Sciences, Faculty of Chemistry, Maria Curie-Skłodowska University, M. Curie-Skłodowska Sq. 3, 20-031 Lublin, PolandAgnieszka SzopaChair and Department of Pharmaceutical Botany, Jagiellonian University, Medical College, Medyczna 9, 30-688 Kraków, Poland

2023en

ABI

Аннотация

Chitosan-based nanoparticles (chitosan-based nanocomposites; chitosan nanoparticles; ChNPs) are promising materials that are receiving a lot of attention in the last decades. ChNPs have great potential as nanocarriers. They are able to encapsulate drugs as well as active compounds and deliver them to a specific place in the body providing a controlled release. In the article, an overview has been made of the most frequently used preparation methods, and the developed applications in medicine. The presentation of the most important information concerning ChNPs, especially chitosan's properties in drug delivery systems (DDS), as well as the method of NPs production was quoted. Additionally, the specification and classification of the NPs' morphological features determined their application together with the methods of attaching drugs to NPs. The latest scientific reports of the DDS using ChNPs administered orally, through the eye, on the skin and transdermally were taken into account.

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Идентификаторы

DOI: 10.3390/molecules28041963

Цитирования и источники

Цитирований: 3Использованных источников: 0

Показатели — AkademScholar