Rapid Synthesis of 3‐Aminoimidazo[1,2‐<i>a</i>]Pyridines and Pyrazines

Abstract p‐Toluenesulfonic acid catalyzed the one‐pot, three‐component synthesis of 3‐aminoimidazo[1,2‐a]pyridines and pyrazines through a condensation reaction of a 2‐aminoazine, an aldehyde, and an isocyanide at room temperature. This methodology affords a number of 3‐aminoimidazo[1,2‐a]pyridines in reasonable yields and short reaction times without any significant optimization of the reaction conditions. Keywords: 3‐Aminoimidazo[1,2‐a]pyridines3‐aminoimidazo[1,2‐a]pyrazinesisocyanide p‐toluenesulfonic acid Acknowledgment We gratefully acknowledge the financial support from the Research Council of Shahid Beheshti University.

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