MicroRNAs in apoptosis, autophagy and necroptosis

// Zhenyi Su 1, 2, * , Zuozhang Yang 3, 4, * , Yongqing Xu 4, * , Yongbin Chen 5, * , Qiang Yu 6, * 1 Department of Biochemistry and Molecular Biology, Medical School, Southeast University, Nanjing, Jiangsu 210009, China 2 Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA 3 Bone and Soft Tissue Tumors Research Center of Yunnan Province, Department of Orthopaedics, the Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, Yunnan 650118, China 4 Department of Orthopaedics, Kunming General Hospital of Chengdu Military Command, Kunming, Yunnan 650118, China 5 Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 6 Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China * These authors have contributed equally to this work Correspondence to: Zuozhang Yang, e-mail: [email protected] Keywords: microRNA, apoptosis, autophagy, necroptosis, cancer progression Received: February 02, 2015      Accepted: March 10, 2015      Published: April 02, 2015 ABSTRACT MicroRNAs (miRNAs) are endogenous 22 nt non-coding RNAs that target mRNAs for cleavage or translational repression. Numerous miRNAs regulate programmed cell death including apoptosis, autophagy and necroptosis. We summarize how miRNAs regulate apoptotic, autophagic and necroptotic pathways and cancer progression. We also discuss how miRNAs link different types of cell death.

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