An unusual sesquiterpene coumarin from the seeds of <i>Ferula sinkiangensis</i>
Guang-Zhi LiInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, ChinaJunchi WangInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, ChinaXiaojin LiXinjiang Institute of Chinese Materia Medica and Ethical Materia Medica, Urumqi 830002, ChinaLi CaoInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, ChinaLi GaoInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, ChinaNa LvInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, ChinaJianyong SiInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China
2016en
ABI
Аннотация
A sesquiterpene coumarin, sinkiangenorin E, consisting of a novel bicyclo[4.3.1]decane-type sesquiterpene system, was isolated from the seeds of Ferula sinkiangensis. The structure of sinkiangenorin E including the relative stereochemistry and the absolute configuration was elucidated on the basis of spectroscopic data. The new compound showed cytotoxic activity against AGS cells (IC50, 12.7 μM) and inhibiting effect against influenza A H1N1 (IC50, 4.0 μM), which provided important clues for the study on the bioactivities of this type of sesquiterpene coumarins.
Перевод пока недоступен
Идентификаторы
Цитирования и источники
Цитирований: 2Использованных источников: 0