Статья

Effect of oleic and linoleic acids on the inflammatory phase of wound healing in rats

Leonardo PereiraDepartment of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, BrazilElaine HatanakaDepartment of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, BrazilEdgair Fernandes MartinsDepartment of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, BrazilFlávia de OliveiraDepartment of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, BrazilÉdson Aparecido LibertiDepartment of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, BrazilSandra Helena Poliselli FarskyDepartment of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of Sao Paulo, BrazilRui CuriDepartment of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, BrazilTânia Cristina Pithon‐CuriCruzeiro do Sul University, Sao Paulo, Brazil

2007en

ABI

Аннотация

Inflammation is a crucial step for the wound healing process. The effect of linoleic and oleic acids on the inflammatory response of the skin during the healing process and on the release of pro-inflammatory cytokines by rat neutrophils in vitro was investigated. A wound in the dorsal surface of adult rats was performed and fatty acids were then topically administered. Both oleic and linoleic acids increased the wound healing tissue mass. The total protein and DNA contents of the wounds were increased by the treatment with linoleic acid. The treatments with oleic and linoleic acids did not affect vascular permeability. However, the number of neutrophils in the wounded area and air pouches was increased and the thickness of the necrotic cell layer edge around the wound was decreased. A dose-dependent increase in vascular endothelial growth factor-alpha (VEGF-alpha) and interleukin-1beta (IL-1beta) by neutrophils incubated in the presence of oleic and linoleic acid was observed. Oleic acid was able to stimulate also the production of cytokine-induced neutrophil chemoattractant in inflammation 2 alpha/beta (CINC-2alpha/beta). This pro-inflammatory effect of oleic and linoleic acids may speed up the wound healing process.

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Идентификаторы

DOI: 10.1002/cbf.1432

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