Обзорная статья

Nanomaterials for bone metastasis

Xinyan HaoDepartment of Orthopaedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China; Xiangya School of Medicine, Central South University, Changsha, Hunan 410011, China; Department of Pharmacy, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, ChinaBuchan JiangDepartment of Orthopaedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China; Hunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, ChinaJunyong WuDepartment of Pharmacy, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, ChinaDaxiong XiangDepartment of Pharmacy, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, ChinaZijian XiongDepartment of Orthopaedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China; Xiangya School of Medicine, Central South University, Changsha, Hunan 410011, China; Hunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, ChinaChenbei LiDepartment of Orthopaedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China; Hunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, ChinaZhaoqi LiDepartment of Orthopaedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China; Hunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, ChinaZhaoqi LiDepartment of Orthopaedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China; Hunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, ChinaShasha HeDepartment of Oncology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China. Electronic address: [email protected]Chao TuDepartment of Orthopaedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China; Hunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China; Changsha Medical University, Changsha 410219, China. Electronic address: [email protected]Zhihong LiDepartment of Orthopaedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China; Hunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, ChinaZhihong LiDepartment of Orthopaedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China; Hunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China

2024en

ABI

Аннотация

Bone metastasis, a prevalent occurrence in primary malignant tumors, is often associated with a grim prognosis. The bone microenvironment comprises various coexisting cell types, working together in a coordinated manner. This dynamic microenvironment plays a pivotal role in the initiation and progression of bone metastases. While cancer therapies have made advancements, the available options for addressing bone metastases remain insufficient. The advent of nanotechnology has ushered in a new era for managing and preventing bone metastases because of the physicochemical and adaptable advantages of nanoplatforms. In this review, we make an introduction of the underlying mechanisms and the current clinical therapies of bone metastases, highlighting the advances of intelligent nanosystems that can stimulate vascular regeneration, promote bone regeneration, eliminate tumor cells, minimize bone damage, and expedite bone healing. The innovation surrounding bone-targeting nanoplatforms presents a fresh approach to the theranostics of bone metastases. Illustration of therapies for bone metastases • The metastatic cascade and the vicious cycle of bone metastases are introduced. • The two-sided role of the bone microenvironment in bone metastases are discussed. • Emerging nanotherapeutics against bone metastases are summarized. • Challenges in using current nanotechnology to manage bone metastases are concluded. • Future frontiers in nanotherapy for bone metastases treatment are highlighted.

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Идентификаторы

DOI: 10.1016/j.jconrel.2024.07.067

Цитирования и источники

Цитирований: 7Использованных источников: 0

Показатели — AkademScholar