Square Wave Cathodic Adsorptive Stripping Voltammetric Determination of the Anticancer Drugs Flutamide and Irinotecan in Biological Fluids Using Renewable Pencil Graphite Electrodes
Y. M. TemerkChemistry Department, Faculty of Science, Assiut University, Assiut, EgyptHossieny IbrahimChemistry Department, Faculty of Science, Assiut University, Assiut, EgyptWolfgang SchuhmannAnalytical Chemistry – Center for Electrochemical Sciences (CES); Ruhr-Universität Bochum, Universitätsstr. 150;, D-44780 Bochum, Germany
2015en
ABI
Аннотация
Abstract A sensitive electrochemical method based on square wave cathodic adsorptive stripping voltammetry (SWCASV) using pencil graphite electrodes (PGE) was developed for the individual and simultaneous determination of the anticancer drugs flutamide (Flu) and irinotecan (Irino) in biological fluids. Calibration curves showed an excellent linear response with limits of detection of 1.68×10 −9 and 1.55×10 −8 M Irino and Flu, respectively. The statistical evaluation of within‐day repeatability (n=5) and day to day precision (n=5) showed satisfactory accuracy and precision. SWCASV using a PGE for individual and simultaneous determination of both drugs in bulk form, human urine and serum samples was demonstrated.
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