Статья

antiSMASH 8.0: extended gene cluster detection capabilities and analyses of chemistry, enzymology, and regulation

Kai BlinThe Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark , 2950 Kongens Lyngby,Simon J. ShawThe Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark , 2950 Kongens Lyngby,Lisa VaderThe Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark , 2950 Kongens Lyngby,Judit SzeneiThe Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark , 2950 Kongens Lyngby,Zachary L. ReitzUniversity of California Department of Ecology, Evolution and Marine Biology, , 1169 Biological Sciences II, Santa Barbara, CA 93106 ,Hannah E. AugustijnBioinformatics Group, , Droevendaalsesteeg 1, 6708 PB Wageningen ,José D D Cediel-BecerraUniversity of FloridaValérie de Crécy‐LagardUniversity of Florida Department of Microbiology and Cell Science, , 1355 Museum Dr, Gainesville , FL 32603 ,Robert A. KoetsierBioinformatics Group, , Droevendaalsesteeg 1, 6708 PB Wageningen ,Sam E. WilliamsThe Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark , 2950 Kongens Lyngby,Pablo Cruz‐MoralesThe Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark , 2950 Kongens Lyngby,Sopida WongwasSchool of Life Sciences, University of Warwick , Coventry CV4 7AL ,Alejandro E Segurado LuchsingerKU Leuven Department of Biology, , Kasteelpark Arenberg 31, 3001 Leuven,Friederike BiermannBioinformatics Group, , Droevendaalsesteeg 1, 6708 PB Wageningen ,Aleksandra KorenskaiaInterfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), Interfaculty Institute for Biomedical Informatics (IBMI), University of Tübingen , Auf der Morgenstelle 24, 72076 Tübingen ,Mitja M. ZdoucBioinformatics Group, , Droevendaalsesteeg 1, 6708 PB Wageningen ,David MeijerBioinformatics Group, , Droevendaalsesteeg 1, 6708 PB Wageningen ,Barbara R. TerlouwBioinformatics Group, , Droevendaalsesteeg 1, 6708 PB Wageningen ,Justin J. J. van der HooftBioinformatics Group, , Droevendaalsesteeg 1, 6708 PB Wageningen ,Nadine ZiemertInterfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), Interfaculty Institute for Biomedical Informatics (IBMI), University of Tübingen , Auf der Morgenstelle 24, 72076 Tübingen ,Eric J. N. HelfrichInstitute of Molecular Bio Science, Goethe-University Frankfurt , Max-von-Laue-Straße 9, 60438 Frankfurt am Main ,Joleen MasscheleinKU Leuven Department of Biology, , Kasteelpark Arenberg 31, 3001 Leuven,Christophe CorreSchool of Life Sciences, University of Warwick , Coventry CV4 7AL ,Marc G. ChevretteUniversity of Florida Department of Microbiology and Cell Science, , 1355 Museum Dr, Gainesville , FL 32603 ,Gilles P. van WezelInstitute of Biology, Leiden University , Sylviusweg 72, 2333 BE Leiden ,Marnix H. MedemaBioinformatics Group, , Droevendaalsesteeg 1, 6708 PB Wageningen ,Tilmann WeberThe Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark , 2950 Kongens Lyngby,

2025en

ABI

Аннотация

Microorganisms synthesize small bioactive compounds through their secondary or specialized metabolism. Those compounds play an important role in microbial interactions and soil health, but are also crucial for the development of pharmaceuticals or agrochemicals. Over the past decades, advancements in genome sequencing have enabled the identification of large numbers of biosynthetic gene clusters directly from microbial genomes. Since its inception in 2011, antiSMASH (https://antismash.secondarymetabolites.org/), has become the leading tool for detecting and characterizing these gene clusters in bacteria and fungi. This paper introduces version 8 of antiSMASH, which has increased the number of detectable cluster types from 81 to 101, and has improved analysis support for terpenoids and tailoring enzymes, as well as improvements in the analysis of modular enzymes like polyketide synthases and nonribosomal peptide synthetases. These modifications keep antiSMASH up-to-date with developments in the field and extend its overall predictive capabilities for natural product genome mining.

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Идентификаторы

DOI: 10.1093/nar/gkaf334

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar