Статья

Orexin Neurons to Sublaterodorsal Tegmental Nucleus Pathway Prevents Sleep Onset REM Sleep-Like Behavior by Relieving the REM Sleep Pressure

Hui FengDepartment of Neurobiology, Army Medical University, 400038 Chongqing, P.R. ChinaQi‐Cheng QiaoDepartment of Physiology, Army Medical University, 400038 Chongqing, P.R. ChinaQi-Fa LuoDepartment of Physiology, Army Medical University, 400038 Chongqing, P.R. ChinaJunying ZhouSleep Medicine Center, West China Hospital, Sichuan University, 610000 Chengdu, Sichuan, P.R. ChinaFei LeiSleep Medicine Center, West China Hospital, Sichuan University, 610000 Chengdu, Sichuan, P.R. ChinaYao ChenDepartment of Physiology, Army Medical University, 400038 Chongqing, P.R. ChinaSi‐Yi WenDepartment of Physiology, Army Medical University, 400038 Chongqing, P.R. ChinaWen‐Hao ChenDepartment of Physiology, Army Medical University, 400038 Chongqing, P.R. ChinaYu-Jie PangDepartment of Physiology, Army Medical University, 400038 Chongqing, P.R. ChinaZhian HuDepartment of Physiology, Army Medical University, 400038 Chongqing, P.R. ChinaYi‐Bin JiangDepartment of Neurosurgery and Key Laboratory of Neurotrauma, Southwest Hospital, Army Medical University, 400038 Chongqing, P.R. ChinaXu-Yang ZhangDepartment of Neurosurgery and Key Laboratory of Neurotrauma, Southwest Hospital, Army Medical University, 400038 Chongqing, P.R. ChinaTengyuan ZhouDepartment of Neurosurgery and Key Laboratory of Neurotrauma, Southwest Hospital, Army Medical University, 400038 Chongqing, P.R. ChinaXinyan ZhangDepartment of Neurosurgery and Key Laboratory of Neurotrauma, Southwest Hospital, Army Medical University, 400038 Chongqing, P.R. ChinaNian YangDepartment of Physiology, Army Medical University, 400038 Chongqing, P.R. ChinaJun ZhangDepartment of Neurobiology, Army Medical University, 400038 Chongqing, P.R. ChinaRong HuCHINA

2024en

ABI

Аннотация

Proper timing of vigilance states serves fundamental brain functions. Although disturbance of sleep onset rapid eye movement (SOREM) sleep is frequently reported after orexin deficiency, their causal relationship still remains elusive. Here, we further study a specific subgroup of orexin neurons with convergent projection to the REM sleep promoting sublaterodorsal tegmental nucleus (OX SLD neurons). Intriguingly, although OX SLD and other projection-labeled orexin neurons exhibit similar activity dynamics during REM sleep, only the activation level of OX SLD neurons exhibits a significant positive correlation with the post-inter-REM sleep interval duration, revealing an essential role for the orexin-sublaterodorsal tegmental nucleus (SLD) neural pathway in relieving REM sleep pressure. Monosynaptic tracing reveals that multiple inputs may help shape this REM sleep-related dynamics of OX SLD neurons. Genetic ablation further shows that the homeostatic architecture of sleep/wakefulness cycles, especially avoidance of SOREM sleep-like transition, is dependent on this activity. A positive correlation between the SOREM sleep occurrence probability and depression states of narcoleptic patients further demonstrates the possible significance of the orexin-SLD pathway on REM sleep homeostasis.

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Идентификаторы

DOI: 10.34133/research.0355

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar