Статья

Comprehensive Analysis of Global Research on Human Varicocele: A Scientometric Approach

Ashok AgarwalAmerican Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USARenata FinelliAmerican Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USADamayanthi DurairajanayagamDepartment of Physiology, Faculty of Medicine, Universiti Teknologi Mara, Sungai Buloh Campus, Selangor, MalaysiaKristian LeisegangDepartment of Physiology, School of Natural Medicine, Faculty of Community and Health Sciences, University of the Western Cape, Bellville, South AfricaRalf HenkelAmerican Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USAGianmaria SalvioDepartment of Endocrinology and Metabolic Diseases, Polytechnic University of Marche, Ancona, ItalyAzin AghamajidiDepartment of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, IranPallav SenguptaDepartment of Physiology, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jenjarom, Selangor, MalaysiaLuís CrisóstomoLaboratory for Integrative and Translational Research in Population Health (ITR), Universidade do Porto, Porto, PortugalPetroula TsioulouDepartment of Physiology, Group of Physiology of Reproduction and Clinical Embryology, Medical School, National and Kapodistrian University of Athens, Athens, GreeceShubhadeep RoychoudhuryDepartment of Life Science and Bioinformatics, Assam University, Silchar, IndiaFederica FinocchiDepartment of Endocrinology and Metabolic Diseases, Polytechnic University of Marche, Ancona, ItalyMahsa DarbandiFilomena MottolaDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania Luigi Vanvitelli, Caserta, ItalySara DarbandiConcetta IovineDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania Luigi Vanvitelli, Caserta, ItalyMarianna SantonastasoDepartment of Women, Children and General and Specialized Surgery, University of Campania Luigi Vanvitelli, Naples, ItalyHimasadat ZakerHistology and Mcroscopic Analysis Division, RASTA Specialized Research Institute (RSRI), West Azerbaijan Science and Technology Park (WASTP), Urmia, IranKavindra Kumar KesariDepartment of Applied Physics, Aalto University, Espoo, FinlandAmir NomanzadehHistology and Mcroscopic Analysis Division, RASTA Specialized Research Institute (RSRI), West Azerbaijan Science and Technology Park (WASTP), Urmia, IranNivita GugnaniBabySoon Fertility and IVF Center, New Delhi, IndiaAmarnath RambhatlaDepartment of Urology, Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI, USAMesut Berkan DuranDepartment of Urology, Samsun Training and Research Hospital, Samsun, TurkeyErman CeyhanDeparment of Urology, Baskent University Faculty of Medicine, Ankara, TurkeyHussein KandilFakih IVF Fertility Center, Abu Dhabi, UAEMohamed ArafaAmerican Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USARamadan SalehAjyal IVF Center, Ajyal Hopsital, Sohag, EgyptRupin ShahDivision of Andrology, Department of Urology, Lilavati Hospital and Research Centre, Mumbai, IndiaEdmund KoDepartment of Urology, Loma Linda University Health, Loma Linda, CA, USAFlorence BoitrelleParis Saclay University, UVSQ, INRAE, BREED, Jouy-en-Josas, France

2022en

ABI

Аннотация

PURPOSE: This study provides a comprehensive analysis of research trends on the etiology, mechanisms, potential risk factors, diagnosis, prognosis, surgical and non-surgical treatment of varicocele, and clinical outcomes before and after varicocele repair. MATERIALS AND METHODS: Varicocele studies published between 1988 and 2020 were retrieved from the Scopus database on April 5, 2021. Original studies on human varicocele were included, irrespective of language. Retrieved articles were manually screened for inclusion in various sub-categories. Bibliometric data was subjected to scientometric analysis using descriptive statistics. Network, heat and geographic mapping were generated using relevant software. RESULTS: In total, 1,943 original human studies on varicocele were published. These were predominantly from the northern hemisphere and developed countries, and published in journals from the United States and Germany. Network map analysis for countries showed several interconnected nodal points, with the USA being the largest, and Agarwal A. from Cleveland Clinic, USA, being a center point of worldwide varicocele research collaborations. Studies of adolescents were underrepresented compared with studies of adults. Studies on diagnostic and prognostic aspects of varicocele were more numerous than studies on varicocele prevalence, mechanistic studies and studies focusing on etiological and risk factors. Varicocele surgery was more investigated than non-surgical approaches. To evaluate the impact of varicocele and its treatment, researchers mainly analyzed basic semen parameters, although markers of seminal oxidative stress are being increasingly investigated in the last decade, while reproductive outcomes such as live birth rate were under-reported in the literature. CONCLUSIONS: This study analyzes the publication trends in original research on human varicocele spanning over the last three decades. Our analysis emphasizes areas for further exploration to better understand varicocele's impact on men's health and male fertility.

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Идентификаторы

DOI: 10.5534/wjmh.210202

Цитирования и источники

Цитирований: 2Использованных источников: 0

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