Обзорная статья

Bioaccumulation of lead (Pb) and its effects on human: A review

Marie CollinDepartment of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, IndiaSenthil Kumar VenkatramanSaveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai 602105, Tamil Nadu, IndiaNaveensubramaniam VijayakumarDepartment of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, IndiaV KanimozhiDepartment of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, IndiaS Muhammad ArbaazDepartment of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, IndiaR G Sibiya StaceyDepartment of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, IndiaJogannagari AnushaDepartment of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, IndiaRajan ChoudharyRudolfs Cimdins Riga Biomaterials Innovations and Development Centre of RTU, Institute of General Chemical Engineering, Faculty of Materials Science and Applied Chemistry, Riga Technical University, Pulka St 3, Riga, LV-1007, LatviaVladislav LvovNational University of Science and Technology “MISIS”, Leninskiy Pr. 4, 119049 Moscow, RussiaGabriel Ibrahin TovarUniversidad de Buenos Aires (UBA), Facultad de Farmacia y Bioquímica, Departamento de Química Analítica y Fisicoquímica, Junín 956, C1113AAD Buenos Aires, ArgentinaFedor SenatovNational University of Science and Technology “MISIS”, Leninskiy Pr. 4, 119049 Moscow, RussiaSivasankar KoppalaSaveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai 602105, Tamil Nadu, IndiaSasikumar SwamiappanDepartment of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, India

2022en

ABI

Аннотация

Lead is a prevalent heavy metal that pollutes the environment and accumulates in the human body via absorption, bioavailability, bioconcentration, and biomagnification disrupts the neurological, skeletal, reproductive, hematopoietic, renal, and cardiovascular systems. Lead's distinctive physical and chemical characteristics make it ideal for a variety of uses. It has been linked to human activities for ages and is harmful to health. This review article examines the long-term health consequences of lead exposure in humans. Acute and chronic symptoms of lead poisoning include kidney, brain, reproductive organ, and CNS/PNS damage. Toxic metals have a long half-life in the bone matrix and brain (2–3 years), causing neurological problems and bone loss. The article also shows the problems of high BPb in both men and women during pregnancy. Renal system blood lead levels of 30–60 g/dL may cause kidney failure in severe circumstances. The oxidative stress that occurs in human cells has also been explored. Finally, lead poisoning and lead buildup prevention and therapy have been reviewed. The use of micronutrients and antioxidants has demonstrated a reduction in harmful effects. Adults with BPb >45 g/dL should have chelation, whereas children should receive succimer.

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Идентификаторы

DOI: 10.1016/j.hazadv.2022.100094

Цитирования и источники

Цитирований: 3Использованных источников: 0

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