Cancer Preventive Agents. Part 5. Anti-tumor-Promoting Effects of Coumarins and Related Compounds on Epstein-Barr Virus Activation and Two-stage Mouse Skin Carcinogenesis
Madoka SuzukiNatural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USAKyoko Nakagawa‐GotoNatural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USASeikou NakamuraNatural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USAHarukuni TokudaDepartment of Biochemistry and Molecular Biology, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, JapanSusan L. Morris‐NatschkeNatural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USAMutsuo KozukaNatural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USAHoyoku NishinoDepartment of Biochemistry and Molecular Biology, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, JapanKuo‐Hsiung LeeNatural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USA
2006en
ABI
Аннотация
A series of coumarins and related compounds were synthesized and screened as potential anti-tumor-promoting agents by examining the ability of the compound to inhibit Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O.-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. The most promising compound in this in vitro. assay, 7,8-di(3-methyl-2-butenyloxy)coumarin (17), showed confirmed chemopreventive activity in an in vivo. two-stage assay of mouse skin tumors (DMBA/TPA). This investigation also confirmed an important role for the prenyl moiety, and, possibly, for the dimethylpyran substructure, on the anti-tumor-promoting activity.
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