Обзорная статья

Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety

Md. Abdul HannanDepartment of Anatomy, Dongguk University College of Medicine, Gyeongju 38066, KoreaMd. Ataur RahmanDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Seoul 02447, KoreaAbdullah Al Mamun SohagDepartment of Biochemistry and Molecular Biology, Bangladesh Agricultural University, Mymensingh 2202, BangladeshMd Jamal UddinABEx Bio-Research Center, East Azampur, Dhaka 1230, BangladeshRaju DashDepartment of Anatomy, Dongguk University College of Medicine, Gyeongju 38066, KoreaMahmudul Hasan SikderDepartment of Pharmacology, Bangladesh Agricultural University, Mymensingh 2202, BangladeshMd Saidur RahmanDepartment of Animal Science & Technology and BET Research Institute, Chung-Ang University, Gyeonggi-do, Anseong 17546, KoreaBinod TimalsinaDepartment of Anatomy, Dongguk University College of Medicine, Gyeongju 38066, KoreaYeasmin Akter MunniDepartment of Anatomy, Dongguk University College of Medicine, Gyeongju 38066, KoreaSourav SarkerABEx Bio-Research Center, East Azampur, Dhaka 1230, BangladeshMahboob AlamDepartment of Anatomy, Dongguk University College of Medicine, Gyeongju 38066, KoreaMd. MohibbullahDepartment of Fishing and Post Harvest Technology, Sher-e-Bangla Agricultural University, Sher-e-Bangla Nagar, Dhaka 1207, BangladeshMd. Nazmul HaqueDepartment of Fisheries Biology and Genetics, Patuakhali Science and Technology University, Patuakhali 8602, BangladeshIsrat JahanDepartment of Pharmacy, Faculty of Life and Earth Sciences, Jagannath University, Dhaka 1100, BangladeshMd. Tahmeed HossainDepartment of Biochemistry and Molecular Biology, Bangladesh Agricultural University, Mymensingh 2202, BangladeshTania AfrinInterdisciplinary Institute for Food Security, Bangladesh Agricultural University, Mymensingh 2202, BangladeshMd. Mahbubur RahmanMd. Tahjib‐Ul‐ArifDepartment of Biochemistry and Molecular Biology, Bangladesh Agricultural University, Mymensingh 2202, BangladeshSarmistha MitraDepartment of Anatomy, Dongguk University College of Medicine, Gyeongju 38066, KoreaDiyah Fatimah OktavianiDepartment of Anatomy, Dongguk University College of Medicine, Gyeongju 38066, KoreaMd Kawsar KhanDepartment of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet 3114, BangladeshHo Jin ChoiDepartment of Anatomy, Dongguk University College of Medicine, Gyeongju 38066, KoreaIl Soo MoonDepartment of Anatomy, Dongguk University College of Medicine, Gyeongju 38066, KoreaBonglee KimDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea

2021en

ABI

Аннотация

L.), a highly valued nutraceutical herb with a wide array of health benefits, has attracted growing interest from health-conscious individuals, the scientific community, and pharmaceutical industries. The pleiotropic pharmacological effects of black cumin, and its main bioactive component thymoquinone (TQ), have been manifested by their ability to attenuate oxidative stress and inflammation, and to promote immunity, cell survival, and energy metabolism, which underlie diverse health benefits, including protection against metabolic, cardiovascular, digestive, hepatic, renal, respiratory, reproductive, and neurological disorders, cancer, and so on. Furthermore, black cumin acts as an antidote, mitigating various toxicities and drug-induced side effects. Despite significant advances in pharmacological benefits, this miracle herb and its active components are still far from their clinical application. This review begins with highlighting the research trends in black cumin and revisiting phytochemical profiles. Subsequently, pharmacological attributes and health benefits of black cumin and TQ are critically reviewed. We overview molecular pharmacology to gain insight into the underlying mechanism of health benefits. Issues related to pharmacokinetic herb-drug interactions, drug delivery, and safety are also addressed. Identifying knowledge gaps, our current effort will direct future research to advance potential applications of black cumin and TQ in health and diseases.

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Идентификаторы

DOI: 10.3390/nu13061784

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar