Overcoming Antigen Escape with CAR T-cell Therapy
Hollie J. Jackson1Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New YorkRenier J. Brentjens1Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York
2015en
ABI
Аннотация
Abstract Summary: Sotillo and colleagues describe the molecular events associated with apparent loss of target antigen expression following CAR T-cell therapy. We propose that broader immune activation is required to prevent outgrowth of tumor antigen escape variants following targeted therapies. Cancer Discov; 5(12); 1238–40. ©2015 AACR. See related article by Sotillo et al., p. 1282.
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