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The Integration of Nanomedicine with Traditional Chinese Medicine: Drug Delivery of Natural Products and Other Opportunities

Muling ZengSchool of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, ChinaDongdong GuoSchool of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, ChinaGuillermo Fernández‐VaroDepartment of Biomedicine, University of Barcelona, 08007 Barcelona, SpainXu ZhangSchool of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, ChinaSiqi FuDepartment of Dermatology, Second Xiangya Hospital Central South University, Changsha 410011, ChinaShijie JuSchool of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, ChinaHuiling YangSchool of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, ChinaXingfei LiuSchool of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, ChinaYachao WangThe Institute of Translational Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People’s Hospital, Shenzhen 518035, ChinaYu ZengDepartment of Neurosurgery, Xiangya Hospital Central South University, Changsha 410008, ChinaGregori CasalsService of Biochemistry and Molecular Genetics, Hospital Clinic Universitari, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Carrer de Villarroel, 170, 08036 Barcelona, SpainEudald CasalsSchool of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China
2022en
ABI

Аннотация

The integration of progressive technologies such as nanomedicine with the use of natural products from traditional medicine (TM) provides a unique opportunity for the longed-for harmonization between traditional and modern medicine. Although several actions have been initiated decades ago, a disparity of reasons including some misunderstandings between each other limits the possibilities of a truly complementation. Herein, we analyze some common challenges between nanomedicine and traditional Chinese medicine (TCM). These challenges, if solved in a consensual way, can give a boost to such harmonization. Nanomedicine is a recently born technology, while TCM has been used by the Chinese people for thousands of years. However, for these disciplines, the regulation and standardization of many of the protocols, especially related to the toxicity and safety, regulatory aspects, and manufacturing procedures, are under discussion. Besides, both TCM and nanomedicine still need to achieve a wider social acceptance. Herein, we first briefly discuss the strengths and weaknesses of TCM. This analysis serves to focus afterward on the aspects where TCM and nanomedicine can mutually help to bridge the existing gaps between TCM and Western modern medicine. As discussed, many of these challenges can be applied to TM in general. Finally, recent successful cases in scientific literature that merge TCM and nanomedicine are reviewed as examples of the benefits of this harmonization.

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