Antiviral activities of glycyrrhizin and its modified compounds against human immunodeficiency virus type 1(HIV-1) and herpes simplex virus type 1(HSV-1) in vitro.
Kazuhiro HirabayashiResearch Laboratory, Minophagen Pharmaceutical Co., Kanagawa, JapanSusumu IwataYamaguchi University, Yamaguchi, JapanHiroatsu MatsumotoYamaguchi University, Yamaguchi, JapanTakeo MoriYamaguchi University, Yamaguchi, JapanShoji ShibataYamaguchi University, Yamaguchi, JapanMasanori BabaYamaguchi University, Yamaguchi, JapanMasahiko ItoYamaguchi University, Yamaguchi, JapanShirô ShigetaYamaguchi University, Yamaguchi, JapanHideki NakashimaYamaguchi University, Yamaguchi, JapanNaoki YamamotoYamaguchi University, Yamaguchi, Japan
1991en
ABI
Аннотация
Chemically modified compounds of glycyrrhizin have been synthesized and evaluated for their inhibitory effect on the replication of human immunodeficiency virus type 1 (HIV-1) and herpes simplex virus type 1 (HSV-1). Among them, the 11-deoxo compound having a heteroannular diene structure at the C and D rings proved as active against HIV-1 as glycyrrhizin in MT-4 and MOLT-4 cells. It completely inhibited HIV-1-induced cytopathogenicity in both cell lines at a concentration of 0.16 mM. The compound was also effective against HSV-1 with a 50% inhibitory concentration of 0.5 mM [corrected].
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