Updated Response Assessment Criteria for High-Grade Gliomas: Response Assessment in Neuro-Oncology Working Group
Patrick Y. WenFrom the Center for Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center; Division of Neurology, Brigham and Women's Hospital; Department of Radiology, Massachusetts General Hospital; Brain Tumor Center, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC; Neuro-Oncology Program, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles; Division of NeuroDavid R. MacdonaldFrom the Center for Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center; Division of Neurology, Brigham and Women's Hospital; Department of Radiology, Massachusetts General Hospital; Brain Tumor Center, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC; Neuro-Oncology Program, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles; Division of NeuroDavid A. ReardonFrom the Center for Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center; Division of Neurology, Brigham and Women's Hospital; Department of Radiology, Massachusetts General Hospital; Brain Tumor Center, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC; Neuro-Oncology Program, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles; Division of NeuroTimothy F. CloughesyFrom the Center for Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center; Division of Neurology, Brigham and Women's Hospital; Department of Radiology, Massachusetts General Hospital; Brain Tumor Center, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC; Neuro-Oncology Program, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles; Division of NeuroA. Gregory SorensenFrom the Center for Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center; Division of Neurology, Brigham and Women's Hospital; Department of Radiology, Massachusetts General Hospital; Brain Tumor Center, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC; Neuro-Oncology Program, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles; Division of NeuroEvanthia GalanisFrom the Center for Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center; Division of Neurology, Brigham and Women's Hospital; Department of Radiology, Massachusetts General Hospital; Brain Tumor Center, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC; Neuro-Oncology Program, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles; Division of NeuroJohn DeGrootFrom the Center for Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center; Division of Neurology, Brigham and Women's Hospital; Department of Radiology, Massachusetts General Hospital; Brain Tumor Center, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC; Neuro-Oncology Program, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles; Division of NeuroWolfgang WickFrom the Center for Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center; Division of Neurology, Brigham and Women's Hospital; Department of Radiology, Massachusetts General Hospital; Brain Tumor Center, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC; Neuro-Oncology Program, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles; Division of NeuroMark R. GilbertFrom the Center for Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center; Division of Neurology, Brigham and Women's Hospital; Department of Radiology, Massachusetts General Hospital; Brain Tumor Center, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC; Neuro-Oncology Program, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles; Division of NeuroAndrew B. LassmanFrom the Center for Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center; Division of Neurology, Brigham and Women's Hospital; Department of Radiology, Massachusetts General Hospital; Brain Tumor Center, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC; Neuro-Oncology Program, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles; Division of NeuroChristina TsienFrom the Center for Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center; Division of Neurology, Brigham and Women's Hospital; Department of Radiology, Massachusetts General Hospital; Brain Tumor Center, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC; Neuro-Oncology Program, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles; Division of NeuroTom MikkelsenFrom the Center for Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center; Division of Neurology, Brigham and Women's Hospital; Department of Radiology, Massachusetts General Hospital; Brain Tumor Center, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC; Neuro-Oncology Program, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles; Division of NeuroEric T. WongFrom the Center for Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center; Division of Neurology, Brigham and Women's Hospital; Department of Radiology, Massachusetts General Hospital; Brain Tumor Center, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC; Neuro-Oncology Program, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles; Division of NeuroMarc C. ChamberlainFrom the Center for Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center; Division of Neurology, Brigham and Women's Hospital; Department of Radiology, Massachusetts General Hospital; Brain Tumor Center, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC; Neuro-Oncology Program, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles; Division of NeuroRoger StuppFrom the Center for Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center; Division of Neurology, Brigham and Women's Hospital; Department of Radiology, Massachusetts General Hospital; Brain Tumor Center, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC; Neuro-Oncology Program, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles; Division of NeuroKathleen R. LambornFrom the Center for Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center; Division of Neurology, Brigham and Women's Hospital; Department of Radiology, Massachusetts General Hospital; Brain Tumor Center, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC; Neuro-Oncology Program, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles; Division of NeuroMichael A. VogelbaumFrom the Center for Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center; Division of Neurology, Brigham and Women's Hospital; Department of Radiology, Massachusetts General Hospital; Brain Tumor Center, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC; Neuro-Oncology Program, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles; Division of NeuroMartin J. van den BentFrom the Center for Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center; Division of Neurology, Brigham and Women's Hospital; Department of Radiology, Massachusetts General Hospital; Brain Tumor Center, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC; Neuro-Oncology Program, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles; Division of NeuroSusan M. ChangFrom the Center for Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center; Division of Neurology, Brigham and Women's Hospital; Department of Radiology, Massachusetts General Hospital; Brain Tumor Center, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC; Neuro-Oncology Program, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles; Division of Neuro
2010en
ABI
Аннотация
Currently, the most widely used criteria for assessing response to therapy in high-grade gliomas are based on two-dimensional tumor measurements on computed tomography (CT) or magnetic resonance imaging (MRI), in conjunction with clinical assessment and corticosteroid dose (the Macdonald Criteria). It is increasingly apparent that there are significant limitations to these criteria, which only address the contrast-enhancing component of the tumor. For example, chemoradiotherapy for newly diagnosed glioblastomas results in transient increase in tumor enhancement (pseudoprogression) in 20% to 30% of patients, which is difficult to differentiate from true tumor progression. Antiangiogenic agents produce high radiographic response rates, as defined by a rapid decrease in contrast enhancement on CT/MRI that occurs within days of initiation of treatment and that is partly a result of reduced vascular permeability to contrast agents rather than a true antitumor effect. In addition, a subset of patients treated with antiangiogenic agents develop tumor recurrence characterized by an increase in the nonenhancing component depicted on T2-weighted/fluid-attenuated inversion recovery sequences. The recognition that contrast enhancement is nonspecific and may not always be a true surrogate of tumor response and the need to account for the nonenhancing component of the tumor mandate that new criteria be developed and validated to permit accurate assessment of the efficacy of novel therapies. The Response Assessment in Neuro-Oncology Working Group is an international effort to develop new standardized response criteria for clinical trials in brain tumors. In this proposal, we present the recommendations for updated response criteria for high-grade gliomas.
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