Plant Sources of Galanthamine: Phytochemical and Biotechnological Aspects
Strahil BerkovUniversity of Barcelona, Faculty of Pharmacy, Department of Natural Products, Plant Biology and Soil Science, Barcelona, SpainL. GeorgievaAgroBioInstitute, Sofia, BulgariaV. KondakovaAgroBioInstitute, Sofia, BulgariaA. AtanassovAgroBioInstitute, Sofia, BulgariaFrançesc ViladomatUniversity of Barcelona, Faculty of Pharmacy, Department of Natural Products, Plant Biology and Soil Science, Barcelona, SpainJaume BastidaUniversity of Barcelona, Faculty of Pharmacy, Department of Natural Products, Plant Biology and Soil Science, Barcelona, SpainCarles CodinaUniversity of Barcelona, Faculty of Pharmacy, Department of Natural Products, Plant Biology and Soil Science, Barcelona, Spain
2009en
ABI
Аннотация
Galanthamine, an Amaryllidaceae type alkaloid, is an AChE inhibitor marketed as a hydrobromide salt for the treatment of Alzheimer's disease, poliomyelitis and other neurological diseases. Although the chemical synthesis of galanthamine has been successfully performed, plants are the main source of its production. The phytochemical and biotechnological aspects of plants currently used for galanthamine production, namely Leucojum aestivum, Narcissus ssp. Ungernia victoris and Lycoris radiata, are summarized in the present paper.
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