Chemical Medicine: Novel 10‐Substituted Cytisine Derivatives with Increased Selectivity for α4β2 Nicotinic Acetylcholine Receptors
Alan P. KozikowskiDrug Discovery Program, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, USA. [email protected]Sheela K. ChellappanDrug Discovery Program, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, USA,Yingxian XiaoDepartment of Pharmacology, Georgetown University, 3900 Reservoir Road, Washington, D. C. 20057, USAKrishna BajjuriDrug Discovery Program, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, USA,Hongbin YuanDrug Discovery Program, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, USA,Kenneth J. KellarDepartment of Pharmacology, Georgetown University, 3900 Reservoir Road, Washington, D. C. 20057, USAPavel A. PetukhovDrug Discovery Program, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, USA, Fax: (+1) 312‐996‐7107
2007en
ABI
Аннотация
Neuronal nicotinic acetylcholine receptors are widely distributed in the central and peripheral nervous systems. Several lines of evidence suggest that the α4β2 nAChRs mediate addiction to nicotine in tobacco smoking. Novel 10-substituted cytisine derivatives with increased selectivity for α4β2 nicotinic acetylcholine receptors were synthesized and may be of use in smoking cessation.
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