Diterpenoids from the Whole Plant of Lagochilus platyacanthus
Chenggang ZhangThe Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, The State Administration of TCM (SATCM) Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Shanghai Key Laboratory of Complex Prescription, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaLu WangResearch Center for Health and Nutrition, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaYe LuThe Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, The State Administration of TCM (SATCM) Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Shanghai Key Laboratory of Complex Prescription, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaZi YeThe Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, The State Administration of TCM (SATCM) Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Shanghai Key Laboratory of Complex Prescription, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaZhu‐Zhen HanThe Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, The State Administration of TCM (SATCM) Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Shanghai Key Laboratory of Complex Prescription, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaHong tao XuThe Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, The State Administration of TCM (SATCM) Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Shanghai Key Laboratory of Complex Prescription, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaGui‐Xin ChouThe Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, The State Administration of TCM (SATCM) Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Shanghai Key Laboratory of Complex Prescription, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China
2015en
ABI
Аннотация
Five new diterpenoids, lagoditerpenes A-E (1-3, 5, 6), along with ten known compounds were isolated from the herb of Lagochilus platyacanthus. The absolute structures of 1-4 and 6 were unequivocally elucidated by extensive spectroscopic analyses in association with single-crystal X-ray diffraction, in which compounds 1 and 2 were the epimers at C-13. Furthermore, in in vitro assays, compounds 1, 2 and 6 showed moderate hemostatic activities by shortening the values of activated partial thromboplastin time.
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