Статья

Antibacterial iridoid glucosides from <i>Eremostachys laciniata</i>

Masoud ModaressiSchool of Pharmacy, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, IranAbbas DelazarSchool of Pharmacy, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, IranHossein NazemiyehSchool of Pharmacy, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, IranFatemeh FathiazadSchool of Pharmacy, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, IranEileen SmithCentre for Pharmacognosy and Phytochemistry, The School of Pharmacy, University of London, 29–39 Brunswick Square, London WC1N 1AX, UKM. Mukhlesur RahmanCentre for Pharmacognosy and Phytochemistry, The School of Pharmacy, University of London, 29–39 Brunswick Square, London WC1N 1AX, UKSimon GibbonsCentre for Pharmacognosy and Phytochemistry, The School of Pharmacy, University of London, 29–39 Brunswick Square, London WC1N 1AX, UKLutfun NaharSchool of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine BT52 1SA, Co. Londonderry, Northern Ireland, UKSatyajit D. SarkerSchool of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine BT52 1SA, Co. Londonderry, Northern Ireland, UK

2008en

ABI

Аннотация

Eremostachys laciniata (L) Bunge (family: Lamiaceae alt. Labiatae; subfamily: Lamioideae) is one of the 15 endemic Iranian herbs of the genus Eremostachys. A decoction of the roots and flowers of E. laciniata has traditionally been taken orally for the treatment of allergies, headache and liver diseases. Three antibacterial iridoid glucosides, phloyoside I (1), phlomiol (2) and pulchelloside I (3) have been isolated from the rhizomes of this plant. The structures of these compounds were elucidated unequivocally by a series of 1D and 2D NMR analyses. The antibacterial activity and brine shrimp toxicity of these compounds were assessed using the resazurin microtitre assay and the brine shrimp lethality assay, respectively. All three iridoid glycosides 1-3 exhibited from low to moderate levels (MIC = 0.05-0.50 mg/mL) of antibacterial activity. Of these compounds, compound 3 was the most active, and displayed antibacterial activity against 9 of 12 different strains tested. The most noteworthy activity of 3 was against Bacillus cereus, penicillin-resistant Escherichia coli, Proteus mirabilis and Staphylococcus aureus with an MIC value of 0.05 mg/mL.

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Идентификаторы

DOI: 10.1002/ptr.2568

Цитирования и источники

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