Статья

A new coronavirus associated with human respiratory disease in China

Fan WuShanghai Public Health Clinical Center, Fudan University, Shanghai, ChinaZhao SuDepartment of Pulmonary and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaBin YuWuhan Center for Disease Control and Prevention, Wuhan, ChinaYanmei ChenShanghai Public Health Clinical Center, Fudan University, Shanghai, ChinaWen WangDepartment of Zoonosis, National Institute for Communicable Disease Control and Prevention, China Center for Disease Control and Prevention, Beijing, ChinaZhi-Gang SongShanghai Public Health Clinical Center, Fudan University, Shanghai, ChinaYi HuDepartment of Pulmonary and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaZhao-Wu TaoDepartment of Pulmonary and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaJun-Hua TianWuhan Center for Disease Control and Prevention, Wuhan, ChinaYuan-Yuan PeiShanghai Public Health Clinical Center, Fudan University, Shanghai, ChinaMing-Li YuanDepartment of Pulmonary and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaYu-Ling ZhangDepartment of Zoonosis, National Institute for Communicable Disease Control and Prevention, China Center for Disease Control and Prevention, Beijing, China. [email protected]Fa-Hui DaiShanghai Public Health Clinical Center, Fudan University, Shanghai, ChinaYi LiuShanghai Public Health Clinical Center, Fudan University, Shanghai, ChinaQimin WangShanghai Public Health Clinical Center, Fudan University, Shanghai, ChinaJiao-Jiao ZhengShanghai Public Health Clinical Center, Fudan University, Shanghai, ChinaLin XuShanghai Public Health Clinical Center, Fudan University, Shanghai, ChinaEdward C. HolmesMarie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and School of Medical Sciences, The University of Sydney, Sydney, New South Wales, AustraliaYǒng-Zhèn ZhāngDepartment of Zoonosis, National Institute for Communicable Disease Control and Prevention, China Center for Disease Control and Prevention, Beijing, China. [email protected]

2020en

ABI

Аннотация

Abstract Emerging infectious diseases, such as severe acute respiratory syndrome (SARS) and Zika virus disease, present a major threat to public health 1–3 . Despite intense research efforts, how, when and where new diseases appear are still a source of considerable uncertainty. A severe respiratory disease was recently reported in Wuhan, Hubei province, China. As of 25 January 2020, at least 1,975 cases had been reported since the first patient was hospitalized on 12 December 2019. Epidemiological investigations have suggested that the outbreak was associated with a seafood market in Wuhan. Here we study a single patient who was a worker at the market and who was admitted to the Central Hospital of Wuhan on 26 December 2019 while experiencing a severe respiratory syndrome that included fever, dizziness and a cough. Metagenomic RNA sequencing 4 of a sample of bronchoalveolar lavage fluid from the patient identified a new RNA virus strain from the family Coronaviridae , which is designated here ‘WH-Human 1’ coronavirus (and has also been referred to as ‘2019-nCoV’). Phylogenetic analysis of the complete viral genome (29,903 nucleotides) revealed that the virus was most closely related (89.1% nucleotide similarity) to a group of SARS-like coronaviruses (genus Betacoronavirus, subgenus Sarbecovirus) that had previously been found in bats in China 5 . This outbreak highlights the ongoing ability of viral spill-over from animals to cause severe disease in humans.

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Идентификаторы

DOI: 10.1038/s41586-020-2008-3

Цитирования и источники

Цитирований: 8Использованных источников: 0

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