Статья

Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites

Hao GuoLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAWei-Chun ChouDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAYunjia LaiDepartment of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAKaixin LiangLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAJason W. TamLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAW. June BrickeyDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USALiang ChenDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USANathan D. MontgomeryDepartment of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAXin LiLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USALauren BohannonDivision of Hematologic Malignancies and Cellular Therapy/BMT, Department of Medicine, Duke University, Durham, NC, USAAnthony D. SungDivision of Hematologic Malignancies and Cellular Therapy/BMT, Department of Medicine, Duke University, Durham, NC, USANelson J. ChaoDivision of Hematologic Malignancies and Cellular Therapy/BMT, Department of Medicine, Duke University, Durham, NC, USAJonathan U. PeledAdult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USAAntonio L. C. GomesAdult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USAMarcel R.M. van den BrinkAdult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USAMatthew J. FrenchDuke Human Vaccine Institute, Duke University, Durham, NC, USAAndrew N. MacintyreDuke Human Vaccine Institute, Duke University, Durham, NC, USAGregory D. SempowskiDuke Human Vaccine Institute, Duke University, Durham, NC, USAXianming TanLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAR. Balfour SartorCenter for Gastrointestinal Biology and Disease, Department of Medicine, Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAKun LüDepartment of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAJenny P.‐Y. TingDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

2020en

ABI

Аннотация

Radioprotective bacteria A common symptom of radiation treatment for cancer is gastrointestinal disruption. The damage caused can become so severe and debilitating that it interrupts treatment. Guo et al. noticed that mice surviving experimental radiation exposure had distinctive taxonomic representation in their gut microbiota. A similar correlation was also observed in a small group of human subjects. Further experiments in mice revealed that some strains of bacteria produced high levels of short-chain fatty acids, which seemed to be dampening inflammatory responses and alleviating the damage caused by reactive oxygen species released by the radiation. A metabolomics analysis also implicated a role for tryptophan metabolic pathways in radiation survivorship. Science , this issue p. eaay9097

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Идентификаторы

DOI: 10.1126/science.aay9097

Цитирования и источники

Цитирований: 2Использованных источников: 0

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