Статья

Risk Factors for Intensive Care Unit Admission and In-hospital Mortality Among Hospitalized Adults Identified through the US Coronavirus Disease 2019 (COVID-19)-Associated Hospitalization Surveillance Network (COVID-NET)

Lindsay KimCoronavirus Disease 2019 (COVID-19) Associated Hospitalization Surveillance Network (COVID-NET) Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USAShikha GargCoronavirus Disease 2019 (COVID-19) Associated Hospitalization Surveillance Network (COVID-NET) Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USAAlissa O’HalloranCoronavirus Disease 2019 (COVID-19) Associated Hospitalization Surveillance Network (COVID-NET) Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USAMichael WhitakerCoronavirus Disease 2019 (COVID-19) Associated Hospitalization Surveillance Network (COVID-NET) Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USAHuong PhamCoronavirus Disease 2019 (COVID-19) Associated Hospitalization Surveillance Network (COVID-NET) Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USAEvan J. AndersonDepartment of Medicine and Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USAIsaac ArmisteadUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado, USANancy M. BennettUniversity of Rochester School of Medicine and Dentistry, Rochester, New York, USALaurie M. BillingOhio Department of Health, Columbus, Ohio, USAKathryn Como‐SabettiMinnesota Department of Health, St. Paul, Minnesota, USAMary HillSalt Lake County Health Department, Salt Lake City, Utah, USASue KimMichigan Department of Health and Human Services, Lansing, Michigan, USAMaya MonroeMaryland Department of Health, Baltimore, Maryland, USAAlison MuseNew York State Department of Health, Albany, New York, USAArthur ReingoldUniversity of California, Berkeley, Berkeley, California, USAWilliam SchaffnerVanderbilt University School of Medicine, Nashville, Tennessee, USAMelissa SuttonOregon Health Authority, Portland, Oregon, USAH. Keipp TalbotVanderbilt University School of Medicine, Nashville, Tennessee, USASalina TorresNew Mexico Department of Health, Santa Fe, New Mexico, USAKimberly Yousey‐HindesRachel HolsteinCoronavirus Disease 2019 (COVID-19) Associated Hospitalization Surveillance Network (COVID-NET) Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USACharisse N CummingsChickasaw Nation Industries, Norman, Oklahoma, USALynnette BrammerCoronavirus Disease 2019 (COVID-19) Associated Hospitalization Surveillance Network (COVID-NET) Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USAAron J. HallCoronavirus Disease 2019 (COVID-19) Associated Hospitalization Surveillance Network (COVID-NET) Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USAAlicia M. FryCoronavirus Disease 2019 (COVID-19) Associated Hospitalization Surveillance Network (COVID-NET) Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USAGayle LangleyCoronavirus Disease 2019 (COVID-19) Associated Hospitalization Surveillance Network (COVID-NET) Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

2020en

ABI

Аннотация

BACKGROUND: Currently, the United States has the largest number of reported coronavirus disease 2019 (COVID-19) cases and deaths globally. Using a geographically diverse surveillance network, we describe risk factors for severe outcomes among adults hospitalized with COVID-19. METHODS: We analyzed data from 2491 adults hospitalized with laboratory-confirmed COVID-19 between 1 March-2 May 2020, as identified through the Coronavirus Disease 2019-Associated Hospitalization Surveillance Network, which comprises 154 acute-care hospitals in 74 counties in 13 states. We used multivariable analyses to assess associations between age, sex, race and ethnicity, and underlying conditions with intensive care unit (ICU) admission and in-hospital mortality. RESULTS: The data show that 92% of patients had ≥1 underlying condition; 32% required ICU admission; 19% required invasive mechanical ventilation; and 17% died. Independent factors associated with ICU admission included ages 50-64, 65-74, 75-84, and ≥85 years versus 18-39 years (adjusted risk ratios [aRRs], 1.53, 1.65, 1.84, and 1.43, respectively); male sex (aRR, 1.34); obesity (aRR, 1.31); immunosuppression (aRR, 1.29); and diabetes (aRR, 1.13). Independent factors associated with in-hospital mortality included ages 50-64, 65-74, 75-84, and ≥ 85 years versus 18-39 years (aRRs, 3.11, 5.77, 7.67, and 10.98, respectively); male sex (aRR, 1.30); immunosuppression (aRR, 1.39); renal disease (aRR, 1.33); chronic lung disease (aRR 1.31); cardiovascular disease (aRR, 1.28); neurologic disorders (aRR, 1.25); and diabetes (aRR, 1.19). CONCLUSIONS: In-hospital mortality increased markedly with increasing age. Aggressive implementation of prevention strategies, including social distancing and rigorous hand hygiene, may benefit the population as a whole, as well as those at highest risk for COVID-19-related complications.

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Идентификаторы

DOI: 10.1093/cid/ciaa1012

Цитирования и источники

Цитирований: 2Использованных источников: 0

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