Autophagy in major human diseases
Daniel J. KlionskyLife Sciences Institute, University of Michigan, Ann Arbor, MI, USAGiulia PetroniDepartment of Radiation Oncology, Weill Cornell Medical College, New York, NY, USARavi K. AmaravadiAbramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USAEric H. BaehreckeDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, USAAndrea BallabioDepartment of Molecular and Human Genetics, Baylor College of Medicine, and Jan and Dan Duncan Neurological Research Institute, Texas Children Hospital, Houston, TX, USAPatricia BoyaMargarita Salas Center for Biological Research, Spanish National Research Council, Madrid, SpainJosé Manuel Bravo‐San PedroCenter for Networked Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, SpainKen CadwellDepartment of Microbiology, New York University Grossman School of Medicine, New York, NY, USAFrancesco CecconiCell Stress and Survival Unit, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center, Copenhagen, DenmarkAugustine M.K. ChoiDivision of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USAMary E. ChoiDivision of Nephrology and Hypertension, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USACharleen T. ChuDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USAPatrice CodognoUniversité de Paris, Paris, FranceMaría Isabel ColomboLaboratorio de Mecanismos Moleculares Implicados en el Tráfico Vesicular y la Autofagia-Instituto de Histología y Embriología (IHEM)-Universidad Nacional de Cuyo, CONICET- Facultad de Ciencias Médicas, Mendoza, ArgentinaAna María CuervoDepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USAVojo DeretićAutophagy Inflammation and Metabolism (AIM, Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, NM, USAIvan ĐikićBuchmann Institute for Molecular Life Sciences, Goethe University, Frankfurt, Frankfurt am Main, GermanyZvulun ElazarDepartment of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, IsraelEeva‐Liisa EskelinenInstitute of Biomedicine, University of Turku, Turku, FinlandGian María FimiaDepartment of Epidemiology, Preclinical Research, and Advanced Diagnostics, National Institute for Infectious Diseases 'L. Spallanzani' IRCCS, Rome, ItalyDavid A. GewirtzDepartment of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USADouglas R. GreenDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USAMalene HansenSanford Burnham Prebys Medical Discovery Institute, Program of Development, Aging, and Regeneration, La Jolla, CA, USAMarja JäätteläCell Death and Metabolism, Center for Autophagy, Recycling & Disease, Danish Cancer Society Research Center, Copenhagen, DenmarkTerje JohansenDepartment of Medical Biology, Molecular Cancer Research Group, University of Tromsø-The Arctic University of Norway, Tromsø, NorwayGábor JuhászDepartment of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, HungaryVassiliki KarantzaMerck & Co., Inc., Kenilworth, NJ, USAClaudine KraftCIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, GermanyGuido KroemerCentre de Recherche des Cordeliers, Equipe Labellisée par la Ligue Contre le Cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, FranceNicholas T. KtistakisSignalling Programme, Babraham Institute, Cambridge, UKSharad KumarCentre for Cancer Biology, University of South Australia, Adelaide, SA, AustraliaCarlos López-Otı́nCentro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, SpainKay F. MacleodThe Ben May Department for Cancer Research, The Gordon Center for Integrative Sciences, W-338, The University of Chicago, Chicago, IL, USAFrank MadeoBioTechMed-Graz, Graz, AustriaJennifer MartinezImmunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USAAlicia MeléndezBiology Department, Queens College, City University of New York, Flushing, NY, USANoboru MizushimaDepartment of Biochemistry and Molecular Biology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanChristian MünzViral Immunobiology, Institute of Experimental Immunology, University of Zurich, Zurich, SwitzerlandJosef PenningerDepartment of Medical Genetics, Life Sciences Institute, University of British Columbia, Vancouver, BC, CanadaRushika M. PereraDepartment of Anatomy, University of California, San Francisco, San Francisco, CA, USAMauro PiacentiniDepartment of Biology, University of Rome "Tor Vergata", Rome, ItalyFulvio ReggioriDepartment of Biomedical Sciences of Cells & Systems, Molecular Cell Biology Section, University of Groningen, University Medical Center Groningen, Groningen, The NetherlandsDavid C. RubinszteinDepartment of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UKKevin M. RyanCancer Research UK Beatson Institute, Glasgow, UKJunichi SadoshimaDepartment of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, Rutgers New Jersey Medical School, Newark, NJ, USALaura SantambrogioCaryl and Israel Englander Institute for Precision Medicine, New York, NY, USALuca ScorranoDepartment of Biology, University of Padova, Padova, ItalyHans‐Uwe SimonDepartment of Clinical Immunology and Allergology, Sechenov University, Moscow, RussiaAnna Katharina SimonThe Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UKAnne SimonsenCentre for Cancer Cell Reprogramming, Institute of Clinical Medicine, University of Oslo, Oslo, NorwayAlexandra StolzBuchmann Institute for Molecular Life Sciences, Goethe University, Frankfurt, Frankfurt am Main, GermanyNektarios TavernarakisDepartment of Basic Sciences, School of Medicine, University of Crete, Heraklion, Crete, GreeceSharon A. ToozeMolecular Cell Biology of Autophagy, The Francis Crick Institute, London, UKTamotsu YoshimoriDepartment of Genetics, Graduate School of Medicine, Osaka University, Suita, JapanJunying YuanDepartment of Cell Biology, Harvard Medical School, Boston, MA, USAZhenyu YueDepartment of Neurology, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USAQing ZhongKey Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Department of Pathophysiology, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai, ChinaLorenzo GalluzziCaryl and Israel Englander Institute for Precision Medicine, New York, NY, USAFederico PietrocolaDepartment of Biosciences and Nutrition, Karolinska Institute, Huddinge, Sweden
2021en
ABI
Аннотация
Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.
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