Статья

Multigenerational epigenetic inheritance in humans: DNA methylation changes associated with maternal exposure to lead can be transmitted to the grandchildren

Arko SenDepartment of Pharmacology, Wayne State University, Detroit, MI 48201Nicole HerediaInstitute of Environmental Health Sciences, Wayne State University, Detroit, MI 48201Marie-Claude SenutInstitute of Environmental Health Sciences, Wayne State University, Detroit, MI 48201Susan LandC. S. Mott Centre for Human Growth and Development, Wayne State University, Detroit, MI 48201Kurt HollocherUnion college, 807 Union St, Schenectady, NY 12308X. R. LuInstitute of Environmental Health Sciences, Wayne State University, Detroit, MI 48201Mary O. DereskiDepartment of Biomedical Sciences, Oakland University William Beaumont School of Medicine, Rochester, MI 48309Douglas M. RudenC. S. Mott Centre for Human Growth and Development, Wayne State University, Detroit, MI 48201

2015en

ABI

Аннотация

We report that the DNA methylation profile of a child's neonatal whole blood can be significantly influenced by his or her mother's neonatal blood lead levels (BLL). We recruited 35 mother-infant pairs in Detroit and measured the whole blood lead (Pb) levels and DNA methylation levels at over 450,000 loci from current blood and neonatal blood from both the mother and the child. We found that mothers with high neonatal BLL correlate with altered DNA methylation at 564 loci in their children's neonatal blood. Our results suggest that Pb exposure during pregnancy affects the DNA methylation status of the fetal germ cells, which leads to altered DNA methylation in grandchildren's neonatal dried blood spots. This is the first demonstration that an environmental exposure in pregnant mothers can have an epigenetic effect on the DNA methylation pattern in the grandchildren.

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Идентификаторы

DOI: 10.1038/srep14466

Цитирования и источники

Цитирований: 2Использованных источников: 0

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