Обзорная статья

Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis

Jing YangDepartment of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China; The First Clinical Medical School of Lanzhou University, Lanzhou, ChinaYa ZhengDepartment of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China; Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, ChinaXi GouDepartment of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China; Gastrointestinal Endoscopy Center, Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, ChinaKe PuDepartment of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China; The First Clinical Medical School of Lanzhou University, Lanzhou, ChinaZhaofeng ChenDepartment of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China; Gastrointestinal Endoscopy Center, Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, ChinaQinghong GuoDepartment of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China; Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, China; Gastrointestinal Endoscopy Center, Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, ChinaRui JiDepartment of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China; Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, China; Gastrointestinal Endoscopy Center, Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, ChinaHaojia WangThe First Clinical Medical School of Lanzhou University, Lanzhou, ChinaYuping WangDepartment of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China; Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, China. Electronic address: [email protected]Yongning ZhouDepartment of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China; Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, China; Gastrointestinal Endoscopy Center, Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China. Electronic address: [email protected]

2020en

ABI

Аннотация

BACKGROUND: An outbreak of coronavirus disease 2019 (COVID-19) occurred in Wuhan, China; the epidemic is more widespread than initially estimated, with cases now confirmed in multiple countries. AIMS: The aim of this meta-analysis was to assess the prevalence of comorbidities in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patients and the risk of underlying diseases in severe patients compared to non-severe patients. METHODS: A literature search was conducted using the databases PubMed, EMBASE, and Web of Science through February 25, 2020. Odds ratios (ORs) and 95% confidence intervals (CIs) were pooled using random-effects models. RESULTS: Seven studies were included in the meta-analysis, including 1 576 infected patients. The results showed the most prevalent clinical symptom was fever (91.3%, 95% CI: 86-97%), followed by cough (67.7%, 95% CI: 59-76%), fatigue (51.0%, 95% CI: 34-68%) and dyspnea (30.4%, 95% CI: 21-40%). The most prevalent comorbidities were hypertension (21.1%, 95% CI: 13.0-27.2%) and diabetes (9.7%, 95% CI: 7.2-12.2%), followed by cardiovascular disease (8.4%, 95% CI: 3.8-13.8%) and respiratory system disease (1.5%, 95% CI: 0.9-2.1%). When compared between severe and non-severe patients, the pooled OR of hypertension, respiratory system disease, and cardiovascular disease were 2.36 (95% CI: 1.46-3.83), 2.46 (95% CI: 1.76-3.44) and 3.42 (95% CI: 1.88-6.22) respectively. CONCLUSION: We assessed the prevalence of comorbidities in the COVID-19 patients and found that underlying disease, including hypertension, respiratory system disease and cardiovascular disease, may be risk factors for severe patients compared with non-severe patients.

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Идентификаторы

DOI: 10.1016/j.ijid.2020.03.017

Цитирования и источники

Цитирований: 3Использованных источников: 0

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