Обзорная статья

Biofabrication with Chitosan

Hyunmin YiCenter for Biosystems Research, University of Maryland Biotechnology Institute, 5115 Plant Sciences Building, College Park, Maryland 20742, Department of Materials Science and Engineering, University of Maryland at College Park, College Park, Maryland 20742, Department of Chemical Engineering, University of Maryland at College Park, College Park, Maryland 20742, The Institute for Systems Research, University of Maryland at College Park, College Park, Maryland 20742, and Department of Electrical andLiqun WuCenter for Biosystems Research, University of Maryland Biotechnology Institute, 5115 Plant Sciences Building, College Park, Maryland 20742, Department of Materials Science and Engineering, University of Maryland at College Park, College Park, Maryland 20742, Department of Chemical Engineering, University of Maryland at College Park, College Park, Maryland 20742, The Institute for Systems Research, University of Maryland at College Park, College Park, Maryland 20742, and Department of Electrical andWilliam E. BentleyCenter for Biosystems Research, University of Maryland Biotechnology Institute, 5115 Plant Sciences Building, College Park, Maryland 20742, Department of Materials Science and Engineering, University of Maryland at College Park, College Park, Maryland 20742, Department of Chemical Engineering, University of Maryland at College Park, College Park, Maryland 20742, The Institute for Systems Research, University of Maryland at College Park, College Park, Maryland 20742, and Department of Electrical andReza GhodssiCenter for Biosystems Research, University of Maryland Biotechnology Institute, 5115 Plant Sciences Building, College Park, Maryland 20742, Department of Materials Science and Engineering, University of Maryland at College Park, College Park, Maryland 20742, Department of Chemical Engineering, University of Maryland at College Park, College Park, Maryland 20742, The Institute for Systems Research, University of Maryland at College Park, College Park, Maryland 20742, and Department of Electrical andGary W. RubloffCenter for Biosystems Research, University of Maryland Biotechnology Institute, 5115 Plant Sciences Building, College Park, Maryland 20742, Department of Materials Science and Engineering, University of Maryland at College Park, College Park, Maryland 20742, Department of Chemical Engineering, University of Maryland at College Park, College Park, Maryland 20742, The Institute for Systems Research, University of Maryland at College Park, College Park, Maryland 20742, and Department of Electrical andJames N. CulverCenter for Biosystems Research, University of Maryland Biotechnology Institute, 5115 Plant Sciences Building, College Park, Maryland 20742, Department of Materials Science and Engineering, University of Maryland at College Park, College Park, Maryland 20742, Department of Chemical Engineering, University of Maryland at College Park, College Park, Maryland 20742, The Institute for Systems Research, University of Maryland at College Park, College Park, Maryland 20742, and Department of Electrical andGregory F. PayneCenter for Biosystems Research, University of Maryland Biotechnology Institute, 5115 Plant Sciences Building, College Park, Maryland 20742, Department of Materials Science and Engineering, University of Maryland at College Park, College Park, Maryland 20742, Department of Chemical Engineering, University of Maryland at College Park, College Park, Maryland 20742, The Institute for Systems Research, University of Maryland at College Park, College Park, Maryland 20742, and Department of Electrical and

2005en

ABI

Аннотация

The traditional motivation for integrating biological components into microfabricated devices has been to create biosensors that meld the molecular recognition capabilities of biology with the signal processing capabilities of electronic devices. However, a different motivation is emerging; biological components are being explored to radically change how fabrication is achieved at the micro- and nanoscales. Here we review biofabrication, the use of biological materials for fabrication, and focus on three specific biofabrication approaches: directed assembly, where localized external stimuli are employed to guide assembly; enzymatic assembly, where selective biocatalysts are enlisted to build macromolecular structure; and self-assembly, where information internal to the biological material guides its own assembly. Also reviewed are recent results with the aminopolysaccharide chitosan, a material that offers a combination of properties uniquely suited for biofabrication. In particular, chitosan can be directed to assemble in response to locally applied electrical signals, and the chitosan backbone provides sites that can be employed for the assembly of proteins, nucleic acids, and virus particles.

Перевод пока недоступен

Идентификаторы

DOI: 10.1021/bm050410l

Цитирования и источники

Цитирований: 4Использованных источников: 0

Показатели — AkademScholar