Обзорная статья

Interactions Between Nanoparticles and Dendritic Cells: From the Perspective of Cancer Immunotherapy

Jianbo JiaKey Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Institute of Environmental Research at Greater Bay, Guangzhou University, Guangzhou, ChinaYi ZhangSchool of Chemistry and Chemical Engineering, Shandong University, Jinan, ChinaXin YanSchool of Chemistry and Chemical Engineering, Shandong University, Jinan, ChinaCuijuan JiangSchool of Environmental Science and Engineering, Shandong University, Jinan, ChinaBing YanKey Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Institute of Environmental Research at Greater Bay, Guangzhou University, Guangzhou, ChinaShumei ZhaiSchool of Chemistry and Chemical Engineering, Shandong University, Jinan, China

2018en

ABI

Аннотация

Dendritic cells (DCs) are the primary antigen-presenting cells and play key roles in the orchestration of the innate and adaptive immune system. Targeting DCs by nanotechnology stands as a promising strategy for cancer immunotherapy. The physicochemical properties of nanoparticles (NPs) influence their interactions with DCs, thus altering the immune outcome of DCs by changing their functions in the processes of maturation, homing, antigen processing and antigen presentation. In this review, we summarize the recent progress in targeting DCs using NPs as a drug delivery carrier in cancer immunotherapy, the recognition of NPs by DCs, and the ways the physicochemical properties of NPs affect DCs' functions. Finally, the molecular pathways in DCs that are affected by NPs are also discussed.

Перевод пока недоступен

Идентификаторы

DOI: 10.3389/fonc.2018.00404

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar