Four-Component Domino Reaction Leading to Multifunctionalized Quinazolines
Bo JiangSchool of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou 221116, Jiangsu, P. R. China, College of Chemistry, Chemical Engineering and Materials Science, Suzhou University, Suzhou 215123, Jiangsu, P. R. China, and Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409-1061Shu‐Jiang TuSchool of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou 221116, Jiangsu, P. R. China, College of Chemistry, Chemical Engineering and Materials Science, Suzhou University, Suzhou 215123, Jiangsu, P. R. China, and Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409-1061Parminder KaurSchool of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou 221116, Jiangsu, P. R. China, College of Chemistry, Chemical Engineering and Materials Science, Suzhou University, Suzhou 215123, Jiangsu, P. R. China, and Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409-1061Walter J. WeverSchool of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou 221116, Jiangsu, P. R. China, College of Chemistry, Chemical Engineering and Materials Science, Suzhou University, Suzhou 215123, Jiangsu, P. R. China, and Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409-1061Guigen LiSchool of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou 221116, Jiangsu, P. R. China, College of Chemistry, Chemical Engineering and Materials Science, Suzhou University, Suzhou 215123, Jiangsu, P. R. China, and Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409-1061
2009en
ABI
Аннотация
A new four-component domino reaction has been discovered. The reaction is easy to perform simply by mixing four common reactants and K(2)CO(3) in ethylene glycol under microwave irradiation. The reaction proceeds rapidly and can be finished within 10-24 min with water as the major byproduct, making workup convenient. Four stereogenic centers with one quaternary carbon-amino function are controlled very well; the stereochemistry was unequivocally determined by X-ray structural analysis. The resulting pyrido[3,4-i]quinazoline derivatives are of importance for organic and medicinal research.
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