An Organocatalyzed Efficient One‐pot Synthesis, Biological Evaluation, and Molecular Docking Studies of 4,4′‐(Arylmethylene)bis‐(3‐methyl‐1‐phenyl‐1<i>H</i>‐pyrazol‐5‐ols)
Pravin S. MahajanDepartment of Chemistry Dr. Babasaheb Ambedkar Marathwada University Aurangabad Maharashtra 431 004 IndiaMukesh D. NikamDepartment of Chemistry Dr. Babasaheb Ambedkar Marathwada University Aurangabad Maharashtra 431 004 IndiaVijay M. KhedkarCombi‐Chem Resource Centre CSIR‐National Chemical Laboratory Pune 411008 IndiaPrakash C. JhaSchool of Chemical Sciences Central University of Gujarat Sector‐30 Gandhinagar 38200 Gujarat IndiaP. V. BadadheDepartment of Chemistry Dr. Babasaheb Ambedkar Marathwada University Aurangabad Maharashtra 431 004 IndiaCharansingh H. GillDepartment of Chemistry Dr. Babasaheb Ambedkar Marathwada University Aurangabad Maharashtra 431 004 India
2016en
ABI
Аннотация
The synthesis of 4,4′‐(arylmethylene)bis‐(3‐methyl‐1‐phenyl‐1 H ‐pyrazol‐5‐ol) derivatives catalyzed by ʟ‐proline is a simple, versatile, and efficient method. In vitro antioxidant, anti‐inflammatory, and antimicrobial activities of compounds 4a , 4b , 4c , 4d , 4e , 4f , 4g , 4h , 4i , 4j were studied. Furthermore, to rationalize the observed anti‐inflammatory activity data, molecular docking study has been performed against COX‐2 enzyme which revealed a good binding affinity for these molecules and could provide an insight into the various bonded and non‐bonded interactions guiding their binding affinity.
Перевод пока недоступен
Идентификаторы
Цитирования и источники
Цитирований: 2Использованных источников: 0